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3MB-PP1

Name: 3MB-PP1
Brand: TargetMol
SKU: T21678
Price: 415 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T21678Cas No. 956025-83-5

3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression and cell division arise by targeting Plk1. 3MB-PP1 specifically inhibits analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase with IC50 of 2 μM. 3MB-PP1 can be used for the research of cell division and hypha formation of Candida albicans.

3MB-PP1

🥰Excellent

Purity: 99.96%

Catalog No. T21678Cas No. 956025-83-5

Pack Size	Price	Availability
5 mg	$48	In Stock
10 mg	$88	In Stock
25 mg	$178	In Stock
50 mg	$283	In Stock
100 mg	$415	In Stock
500 mg	Preferential	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.96%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression and cell division arise by targeting Plk1. 3MB-PP1 specifically inhibits analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase with IC50 of 2 μM. 3MB-PP1 can be used for the research of cell division and hypha formation of Candida albicans.
Targets&IC50	Leu93-ZIPK:2 μM
In vitro	In a strain bearing analog-sensitive alleles of SSN3(Cdk8), 3MB-PP1 (5 μM) stimulates hyphal growth[1].

Chemical Properties

Molecular Weight	295.38
Formula	C₁₇H₂₁N₅
Cas No.	956025-83-5
Smiles	Cc1cccc(Cc2nn(c3ncnc(N)c23)C(C)(C)C)c1
Relative Density.	1.209g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (186.2 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3855 mL	16.9273 mL	33.8547 mL	169.2735 mL
5 mM	0.6771 mL	3.3855 mL	6.7709 mL	33.8547 mL
10 mM	0.3385 mL	1.6927 mL	3.3855 mL	16.9273 mL
20 mM	0.1693 mL	0.8464 mL	1.6927 mL	8.4637 mL
50 mM	0.0677 mL	0.3385 mL	0.6771 mL	3.3855 mL
100 mM	0.0339 mL	0.1693 mL	0.3385 mL	1.6927 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc