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3MB-PP1

Catalog No. T21678 CAS 956025-83-5

3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression and cell division arise by targeting Plk1. 3MB-PP1 specifically inhibits analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase with IC50 of 2 μM. 3MB-PP1 can be used for the research of cell division and hypha formation of Candida albicans.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

3MB-PP1, CAS 956025-83-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 147.00
25 mg	In stock	$ 297.00
50 mg	In stock	$ 472.00
100 mg	In stock	$ 693.00
500 mg	In stock	$ 1,460.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Purity: 99.97%

Biological Description

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Description

In vitro

In a strain bearing analog-sensitive alleles of SSN3(Cdk8), 3MB-PP1 (5 μM) stimulates hyphal growth[1].

Molecular Weight	295.38
Formula	C17H21N5
CAS No.	956025-83-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (186.2 mM)

References and Literature

1. Al-Ghabkari A, et al. Validation of chemical genetics for the study of zipper-interacting protein kinase signaling. Proteins. 2018 Nov;86(11):1211-1217. 2. Burkard ME, et al. Enabling and disabling polo-like kinase 1 inhibition through chemical genetics. ACS Chem Biol. 2012 Jun 15;7(6):978-81. 3. Hollomon JM, et al. The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway. PLoS Genet. 2022;18(1):e1009622. Published 2022 Jan 4.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

3MB-PP1 956025-83-5 Cell Cycle/Checkpoint PLK DAPK Inhibitor Polo-like Kinase (PLK) Cdk8 Leu93-ZIPK Plk1 Ssn3 3MBPP1 inhibit CDK 3MB PP1 Death associated protein kinase cell division arise Cyclin dependent kinase Candida albicans inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.