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FGFR1 Protein, Human, Recombinant (His), Biotinylated
(Synonyms: OGD, N-SAM, KAL2, HRTFDS, HH2, HBGFR, FLT-2, FLT2, FLG, fibroblast growth factor receptor 1, FGFR-1, FGFBR, CEK, CD331, bFGF-R-1, BFGFR) Copy Product InfoSynonyms: OGD, N-SAM, KAL2, HRTFDS, HH2, HBGFR, FLT-2, FLT2, FLG, fibroblast growth factor receptor 1, FGFR-1, FGFBR, CEK, CD331, bFGF-R-1, BFGFR
Catalog No. TMPY-05761 Copy Product Info
FGFR1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31 kDa and the accession number is H9FRD4.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $112 | 7-10 days | 7-10 days | |
| 10 µg | $183 | 7-10 days | 7-10 days | |
| 20 µg | $306 | 7-10 days | 7-10 days | |
| 50 µg | $492 | 7-10 days | 7-10 days | |
| 100 µg | $842 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | FGFR1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31 kDa and the accession number is H9FRD4. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | H9FRD4 |
| Construction | A DNA sequence encoding the human FGFR1 (NP_075594.1) extracellular domain (Met1-Glu285) was expressed with C-terminal polyhistidine tag. The purified protein was biotinylated in vitro. Predicted N terminal: Arg 22 |
| Protein Purity | > 95 % as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Synonyms | OGD, N-SAM, KAL2, HRTFDS, HH2, HBGFR, FLT-2, FLT2, FLG, fibroblast growth factor receptor 1, FGFR-1, FGFBR, CEK, CD331, bFGF-R-1, BFGFR |
| Research Background | FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glycosaminoglycans, which facilitates dimerization (activation) of FGF receptors. FGFR1 is a full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR1 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. CD331 can be detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. Defects in FGFR1 are a cause of Pfeiffer syndrome ，idiopathic hypogonadotropic hypogonadism， Kallmann syndrome type 2, osteoglophonic dysplasia and trigonocephaly non-syndromic.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Molecular Weight | 31 kDa (predicted) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: FGFR1 Protein, Human, Recombinant (His), Biotinylated chemical structure | FGFR1 Protein, Human, Recombinant (His), Biotinylated molecular weight
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