Powder: -20°C for 3 years | In solvent: -80°C for 1 year
2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 µM against ErbB-2. It achieves covalent inactivation of ErbB-1 through modification of a cysteine residue within the enzyme's active site [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,670.00 | |
50 mg | 8-10 weeks | $ 2,180.00 | |
100 mg | 8-10 weeks | $ 2,800.00 |
Description | 2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 µM against ErbB-2. It achieves covalent inactivation of ErbB-1 through modification of a cysteine residue within the enzyme's active site [1]. |
Targets&IC50 | ErbB2:45 μM |
In vitro | 2'-Thioadenosine (50 µM) exhibits no activity towards the receptor tyrosine kinases of FGF, PDGF, and insulin [1]. However, it causes the covalent inactivation of ErbB-1, which can be reversed by 1 mM Dithiothreitol [1]. |
Synonyms | PD157432 |
Molecular Weight | 283.31 |
Formula | C10H13N5O3S |
CAS No. | 136904-69-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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2′-Thioadenosine 136904-69-3 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR PD157432 inhibitor inhibit