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LE 300

Name: LE 300
Brand: TargetMol
SKU: T22921
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22921Cas No. 274694-98-3

LE 300 represents a structurally novel type of antagonists acting preferentially at the dopamine D(1)/D(5)receptors and the serotonin 5-HT(2A)receptor.

LE 300

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Purity: 98.79%

Catalog No. T22921Cas No. 274694-98-3

LE 300 represents a structurally novel type of antagonists acting preferentially at the dopamine D(1)/D(5)receptors and the serotonin 5-HT(2A)receptor.

Pack Size	Price	Availability
1 mg	$89	In Stock
5 mg	$219	In Stock
10 mg	$326	In Stock
25 mg	$546	In Stock
50 mg	$778	In Stock
100 mg	$1,060	In Stock
500 mg	$2,120	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.79%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	LE 300 represents a structurally novel type of antagonists acting preferentially at the dopamine D(1)/D(5)receptors and the serotonin 5-HT(2A)receptor.
Targets&IC50	D5 receptor:7.5 nM (Ki,Human), D1 receptor:1.9 nM (Ki,Human), 5-HT2A:8.32 (pA2,rat)
In vitro	The Kis of LE 300 are 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively. In a rat tail artery experiment, the pA2 value of LE 300 at the 5-HT2A receptor was 8.32[2].

Chemical Properties

Molecular Weight	290.4
Formula	C₂₀H₂₂N₂
Cas No.	274694-98-3
Smiles	CN(CCc1c(C2)[nH]c3c1cccc3)CCc1c2cccc1
Relative Density.	1.114g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: <30 mg/mL (103.30 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4435 mL	17.2176 mL	34.4353 mL	172.1763 mL
5 mM	0.6887 mL	3.4435 mL	6.8871 mL	34.4353 mL
10 mM	0.3444 mL	1.7218 mL	3.4435 mL	17.2176 mL
20 mM	0.1722 mL	0.8609 mL	1.7218 mL	8.6088 mL
50 mM	0.0689 mL	0.3444 mL	0.6887 mL	3.4435 mL
100 mM	0.0344 mL	0.1722 mL	0.3444 mL	1.7218 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc