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LE 300

Name: LE 300
Brand: TargetMol
SKU: T22921
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22921Cas No. 274694-98-3

LE 300 represents a structurally novel type of antagonists acting preferentially at the dopamine D(1)/D(5)receptors and the serotonin 5-HT(2A)receptor.

LE 300

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Purity: 98.79%

Catalog No. T22921Cas No. 274694-98-3

LE 300 represents a structurally novel type of antagonists acting preferentially at the dopamine D(1)/D(5)receptors and the serotonin 5-HT(2A)receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$89	In Stock	In Stock
5 mg	$219	In Stock	In Stock
10 mg	$326	In Stock	In Stock
25 mg	$546	In Stock	In Stock
50 mg	$778	In Stock	In Stock
100 mg	$1,060	In Stock	In Stock
500 mg	$2,120	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.79%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	LE 300 represents a structurally novel type of antagonists acting preferentially at the dopamine D(1)/D(5)receptors and the serotonin 5-HT(2A)receptor.
Targets&IC50	D5 receptor:7.5 nM (Ki,Human), 5-HT2A:8.32 (pA2,rat), D1 receptor:1.9 nM (Ki,Human)
In vitro	The Kis of LE 300 are 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively. In a rat tail artery experiment, the pA2 value of LE 300 at the 5-HT2A receptor was 8.32[2].

Chemical Properties

Molecular Weight	290.4
Formula	C₂₀H₂₂N₂
Cas No.	274694-98-3
Smiles	CN(CCc1c(C2)[nH]c3c1cccc3)CCc1c2cccc1
Relative Density.	1.114g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: <30 mg/mL (103.30 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4435 mL	17.2176 mL	34.4353 mL	172.1763 mL
5 mM	0.6887 mL	3.4435 mL	6.8871 mL	34.4353 mL
10 mM	0.3444 mL	1.7218 mL	3.4435 mL	17.2176 mL
20 mM	0.1722 mL	0.8609 mL	1.7218 mL	8.6088 mL
50 mM	0.0689 mL	0.3444 mL	0.6887 mL	3.4435 mL
100 mM	0.0344 mL	0.1722 mL	0.3444 mL	1.7218 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc