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N-Benzylpalmitamide
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Catalog No. T3S2105Cas No. 74058-71-2
Alias N-Benzylhexadecanamide, Macamide 1
N-Benzylpalmitamide (Macamide 1) inhibits fatty acid amide hydrolase (FAAH) in a time-dependent manner and could potentially offer a good alternative for the treatment of pain, inflammation and CNS degenerative disorders.
N-Benzylpalmitamide
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Purity: 99.77%
Catalog No. T3S2105Alias N-Benzylhexadecanamide, Macamide 1Cas No. 74058-71-2
N-Benzylpalmitamide (Macamide 1) inhibits fatty acid amide hydrolase (FAAH) in a time-dependent manner and could potentially offer a good alternative for the treatment of pain, inflammation and CNS degenerative disorders.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $44 | In Stock | In Stock | |
| 10 mg | $64 | In Stock | In Stock | |
| 25 mg | $106 | In Stock | In Stock | |
| 50 mg | $157 | In Stock | In Stock | |
| 100 mg | $233 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.77%
Appearance:Solid
Color:White
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Product Introduction
N-Benzylpalmitamide AI Summary
N-Benzylpalmitamide shows inhibition of human recombinant FAAH (Fatty Acid Amide Hydrolase) activity, with varying levels of inhibition at different concentrations when tested using N-arachidonyl-7-amino-4-methylcoumarin as a substrate in a fluorescence assay. At 500 uM and 10 uM, the inhibition was 43.8% and 24.8%, respectively. Its IC50 value is higher than 500,000.0 nM. The compound also displays antiproliferative activity against various human cancer cell lines (MCF7, NCI/ADR-RES, 786-0, NCI-H460, PC3, OVCAR3, U251) and cytotoxicity against HaCaT cells, with tumor growth inhibition at concentrations greater than 250.0 µg/mL. Furthermore, N-Benzylpalmitamide exhibits inhibitory activity against soluble epoxide hydrolase (sEH) in mouse, rat, and human assays, with IC50 values of 422.0 nM, 370.0 nM, and 524.0 nM, respectively. It also shows cytotoxicity against human THP-1 cells, reducing cell viability after 72 hours incubation with a CC50 value of 100,000.0 nM, and inhibits LPS-induced TNFalpha production in THP-1 cells, with an IC50 of 43,100.0 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | N-Benzylpalmitamide (Macamide 1) inhibits fatty acid amide hydrolase (FAAH) in a time-dependent manner and could potentially offer a good alternative for the treatment of pain, inflammation and CNS degenerative disorders. |
| Synonyms | N-Benzylhexadecanamide, Macamide 1 |
| Molecular Weight | 345.56 |
| Formula | C23H39NO |
| Cas No. | 74058-71-2 |
| Smiles | CCCCCCCCCCCCCCCC(=O)NCc1ccccc1 |
| Relative Density. | 0.919 g/cm3 (Predicted) |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Slightly soluble  |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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