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Anti-Cathepsin L Antibody (1W943)
😃Good
Catalog No. TMAY-00891
Alias nkt, MEP, fs, Ctsl1, cathepsin L, 1190035F06Rik
Anti-Cathepsin L Antibody (1W943) is a Rabbit antibody targeting Cathepsin L. Anti-Cathepsin L Antibody (1W943) can be used in ELISA.
Anti-Cathepsin L Antibody (1W943)
Anti-Cathepsin L Antibody (1W943)
😃Good
Catalog No. TMAY-00891Alias nkt, MEP, fs, Ctsl1, cathepsin L, 1190035F06Rik
Anti-Cathepsin L Antibody (1W943) is a Rabbit antibody targeting Cathepsin L. Anti-Cathepsin L Antibody (1W943) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $270 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Cathepsin L Antibody (1W943) is a Rabbit antibody targeting Cathepsin L. Anti-Cathepsin L Antibody (1W943) can be used in ELISA. |
| Alias | nkt, MEP, fs, Ctsl1, cathepsin L, 1190035F06Rik |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 1W943 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human Cathepsin L / CTSL / CTSL1 (rh Cathepsin L / CTSL / CTSL1; TMPY-00734; NP_001903.1; Met1-Val333). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Cathepsin L is a lysosomal cysteine protease that plays a major role in intracellular protein catabolism, and is potent in degrading collagen, laminin, elastin, as well as alpha-1 protease inhibitor and other structural proteins of basement membranes. It is secreted by liver flukes at all stages of their development in the mammalian host, are believed to play important roles in facilitating parasite migration (tissue degradation), feeding and immuno-evasion. Like many proteases, Cathepsin L is synthesized as an inactive preproenzyme, and cleavage of the 96-residue proregion is necessary to generate the fully active 221-residue mature enzyme. Studies have demonstrated that cleavage of the proregion occur autocatalytically under acidic conditions. The enzyme takes part in nutrient acquisition by catabolizing host proteins to absorbable peptides, facilitates the migration of the parasite through the host intestine and liver by cleaving interstitial matrix proteins such as fibronectin, laminin and native collagen and is implicated in the inactivation of host immune defenses by cleaving immunoglobulins. Recently, Cathepsin L has been shown to suppress Th1 immune response in infected laboratory animals making them susceptible to concurrent bacterial infections. Cathepsin L is synthesized in large amounts and secreted by many malignantly transformed cells, and induced by growth factors and tumor promoters. In addition to its role in protein degradation, evidence has accumulated for the participation of Cathepsin L in various physiological and pathological processes, such as tumor invasion and metastasis, bone resorption, spermatogenesis, and arthritis. Accordingly, Cathepsin L may prove useful as a diagnostic or prognostic marker of human tumor malignancy. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human Cathepsin L / CTSL / CTSL1 protein (TMPY-00734) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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