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Astragalin

Name: Astragalin
Brand: TargetMol
SKU: T6S1101
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6S1101Cas No. 480-10-4

Alias kaempferol-3-glucoside, Kaempferol 3-β-D-glucopyranoside, Kaempferol 3-O-glucoside, Kaempferol 3-D-glucoside, Astragaline, 3-Glucosylkaempferol

Astragalin (Kaempferol 3-O-glucoside) is a biologically active natural flavonoid. It has a variety of pharmacological properties, including antioxidant, anti-inflammatory, anti-cancer, neuroprotective, and cardioprotective properties.

Astragalin

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Purity: 99.91%

Catalog No. T6S1101Alias kaempferol-3-glucoside, Kaempferol 3-β-D-glucopyranoside, Kaempferol 3-O-glucoside, Kaempferol 3-D-glucoside, Astragaline, 3-GlucosylkaempferolCas No. 480-10-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$59	In Stock	In Stock
10 mg	$83	In Stock	In Stock
25 mg	$135	In Stock	In Stock
50 mg	$198	-	In Stock
100 mg	$292	-	In Stock
500 mg	$717	-	In Stock
1 mL x 10 mM (in DMSO)	$70	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Astragalin AI Summary

Astragalin is a multifaceted bioactive agent exhibiting a variety of pharmacological activities. It shows significant antiviral activity, particularly against HIV-1 IIIB replication in H9 cells (EC50 = 80.0 µg/mL) and influenza virus type A H1N1 in MDCK cells (IC50 values ranging from 24.5 to 35.8 µg/mL). It also inhibits mushroom tyrosinase diphenolase (IC50 = 0.074 mM), aldose reductase (IC50 = 5090.0 nM), and angiotensin-converting enzyme (ACE) in rat lung (IC50 = 180.0 µg/mL). In terms of antioxidant properties, Astragalin exhibits DPPH radical scavenging activity (IC50 > 100 µg/mL) and shows activity in ABTS assays (1.46 mM TEAC). Moreover, it demonstrates cytotoxicity against various cell lines, including mouse P388 cells (ED50 = 8.2 µg/mL), and exhibits anti-inflammatory effects by reducing nitric oxide and TNF-alpha levels in mouse RAW264.7 cells. The compound possesses notable antiprotozoal activity against Entamoeba histolytica and Giardia lamblia, with IC50 values of 61.2 and 47.5 µg/mL, respectively. Additionally, Astragalin shows promising antitubercular potential against Mycobacterium tuberculosis H37Rv (MIC > 128.0 µg/mL). In terms of metabolic effects, this compound reduces various fat depots and liver and plasma triglycerides in ddY mice. Additionally, it enhances adipogenesis in mouse 3T3L1 cells and shows neuroprotective properties by enhancing NGF secretion in rat C6 cells. It also plays a role in inhibiting various enzymes such as carbonic anhydrases and protein tyrosine phosphatases, thus demonstrating a broad enzymatic inhibitory profile. Furthermore, Astragalin shows anti-infective actions against Trypanosoma cruzi, with selective inhibitory concentrations for different forms and observable reductions in parasitemia in mouse models. The compound also exhibits selective cytotoxicity against various human cancer cell lines, including U251 and U87MG. Overall, Astragalin is a potent multi-target agent with a broad spectrum of biological activities, making it a compelling candidate for further pharmacological and therapeutic investigations..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Astragalin (Kaempferol 3-O-glucoside) is a biologically active natural flavonoid. It has a variety of pharmacological properties, including antioxidant, anti-inflammatory, anti-cancer, neuroprotective, and cardioprotective properties.
Synonyms	kaempferol-3-glucoside, Kaempferol 3-β-D-glucopyranoside, Kaempferol 3-O-glucoside, Kaempferol 3-D-glucoside, Astragaline, 3-Glucosylkaempferol

Chemical Properties

Molecular Weight	448.38
Formula	C₂₁H₂₀O₁₁
Cas No.	480-10-4
Smiles	OCC1OC(Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)cc2)C(O)C(O)C1O
Relative Density.	1.79 g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (446.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2303 mL	11.1513 mL	22.3025 mL	111.5126 mL
5 mM	0.4461 mL	2.2303 mL	4.4605 mL	22.3025 mL
10 mM	0.2230 mL	1.1151 mL	2.2303 mL	11.1513 mL
20 mM	0.1115 mL	0.5576 mL	1.1151 mL	5.5756 mL
50 mM	0.0446 mL	0.2230 mL	0.4461 mL	2.2303 mL
100 mM	0.0223 mL	0.1115 mL	0.2230 mL	1.1151 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc