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ZM39923
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Catalog No. T17295Cas No. 273727-89-2
Alias ZM-39923, ZM 39923
ZM39923 is an effective JAK3 inhibitor (IC50=79 nM), simultaneously inhibiting TGM2 and Factor XIIIa (IC50=10/25 nM), and also exhibits weak inhibitory activity against EGFR, JAK1, and CDK4 (IC50=2.4/40/10 µM).
ZM39923
😃Good
Catalog No. T17295Alias ZM-39923, ZM 39923Cas No. 273727-89-2
ZM39923 is an effective JAK3 inhibitor (IC50=79 nM), simultaneously inhibiting TGM2 and Factor XIIIa (IC50=10/25 nM), and also exhibits weak inhibitory activity against EGFR, JAK1, and CDK4 (IC50=2.4/40/10 µM).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 4-6 weeks | 4-6 weeks | |
| 50 mg | $1,980 | 4-6 weeks | 4-6 weeks | |
| 100 mg | $2,500 | 4-6 weeks | 4-6 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ZM39923 is an effective JAK3 inhibitor (IC50=79 nM), simultaneously inhibiting TGM2 and Factor XIIIa (IC50=10/25 nM), and also exhibits weak inhibitory activity against EGFR, JAK1, and CDK4 (IC50=2.4/40/10 µM). |
| Targets&IC50 | Factor XIIIa:25 nM, CDK4:10 μM, JAK1:40 μM, JAK3:79 nM, EGFR:2.4 μM, TGM2:10 nM |
| In vitro | ZM39923 blocks the phosphorylation of JAK3 induced by CCL19, and such an effect is similar to that of CCR7 antibody. ZM39923 also significantly blocks the CCL19 induced wound closure rate, and decreases the migration and invasion of PCI-37B cells[3]. |
| Synonyms | ZM-39923, ZM 39923 |
| Molecular Weight | 331.45 |
| Formula | C23H25NO |
| Cas No. | 273727-89-2 |
| Smiles | O=C(C=1C=CC=2C=CC=CC2C1)CCN(CC=3C=CC=CC3)C(C)C |
| Relative Density. | 1.083 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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