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ZM39923
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Catalog No. T17295Cas No. 273727-89-2
Alias ZM-39923, ZM 39923
ZM39923 is an effective JAK3 inhibitor (IC50=79 nM), simultaneously inhibiting TGM2 and Factor XIIIa (IC50=10/25 nM), and also exhibits weak inhibitory activity against EGFR, JAK1, and CDK4 (IC50=2.4/40/10 µM).
ZM39923
Copy Product Info😃Good
Catalog No. T17295Alias ZM-39923, ZM 39923Cas No. 273727-89-2
ZM39923 is an effective JAK3 inhibitor (IC50=79 nM), simultaneously inhibiting TGM2 and Factor XIIIa (IC50=10/25 nM), and also exhibits weak inhibitory activity against EGFR, JAK1, and CDK4 (IC50=2.4/40/10 µM).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 4-6 weeks | 4-6 weeks | |
| 50 mg | $1,980 | 4-6 weeks | 4-6 weeks | |
| 100 mg | $2,500 | 4-6 weeks | 4-6 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ZM39923 is an effective JAK3 inhibitor (IC50=79 nM), simultaneously inhibiting TGM2 and Factor XIIIa (IC50=10/25 nM), and also exhibits weak inhibitory activity against EGFR, JAK1, and CDK4 (IC50=2.4/40/10 µM). |
| Targets&IC50 | Factor XIIIa:25 nM, CDK4:10 μM, JAK1:40 μM, JAK3:79 nM, EGFR:2.4 μM, TGM2:10 nM |
| In vitro | ZM39923 blocks the phosphorylation of JAK3 induced by CCL19, and such an effect is similar to that of CCR7 antibody. ZM39923 also significantly blocks the CCL19 induced wound closure rate, and decreases the migration and invasion of PCI-37B cells[3]. |
| Synonyms | ZM-39923, ZM 39923 |
| Molecular Weight | 331.45 |
| Formula | C23H25NO |
| Cas No. | 273727-89-2 |
| Smiles | O=C(C=1C=CC=2C=CC=CC2C1)CCN(CC=3C=CC=CC3)C(C)C |
| Relative Density. | 1.083 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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