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BI-135585
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Catalog No. T26794Cas No. 1114561-85-1
Alias BI135585, BI 135585
BI-135585 is an orally active, selective and potent inhibitor of human 11β-hydroxysteroid dehydrogenase-1 (HSD1) for the study of type 2 diabetes.
BI-135585
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Purity: 99.57%
Catalog No. T26794Alias BI135585, BI 135585Cas No. 1114561-85-1
BI-135585 is an orally active, selective and potent inhibitor of human 11β-hydroxysteroid dehydrogenase-1 (HSD1) for the study of type 2 diabetes.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $290 | In Stock | In Stock | |
| 5 mg | $650 | In Stock | In Stock | |
| 10 mg | $980 | In Stock | In Stock | |
| 25 mg | $1,670 | In Stock | In Stock | |
| 50 mg | $2,180 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.57%
ee:100%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BI-135585 is an orally active, selective and potent inhibitor of human 11β-hydroxysteroid dehydrogenase-1 (HSD1) for the study of type 2 diabetes. |
| Targets&IC50 | the enzyme activity in abdominal subcutaneous adipose tissue (cynomolgus monkey):100 nM, conversion of corticosterone to cortisol:11 nM, 11β-HSD1:1 nM, the enzyme activity in perirenal adipose tissue (cynomolgus monkey):10 nM |
| In vitro | BI-135585 interacts with the substrate binding pocket of the 11β-HSD1 active site. In human preadipocytes, its inhibition of 11β-HSD1 activity was evaluated and found to have an average IC50 of 1 nM. In isolated human adipose tissue, BI-135585 blocked the conversion of corticosterone to cortisol at an average IC50 of 11 nM. [1] A study of abdominal subcutaneous and perirenal adipose tissue from a male cynomolgus monkey showed that BI-135585 (20 hours of action) exhibited dose-dependent inhibition of the enzyme activity in perirenal adipose tissue with an IC50 of approximately 10 nM, while in abdominal subcutaneous adipose tissue the IC50 was approximately 100 nM.[1] |
| In vivo | BI-135585 (compound 11j; 1-3 mg/kg; orally) inhibited the enzyme activity in perirenal adipose tissue of cynomolgus monkeys by 67% and 90%, respectively. [2] |
| Synonyms | BI135585, BI 135585 |
| Molecular Weight | 460.57 |
| Formula | C28H32N2O4 |
| Cas No. | 1114561-85-1 |
| Smiles | C(C(C)(C)O)[C@]1(OC(=O)N([C@@H](C)C2=CC=C(C=C2)C3=CC(=O)N(C)C=C3)CC1)C4=CC=CC=C4 |
| Relative Density. | no data available |
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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