Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vonoprazan hydrochloride, a proton pump inhibitor (PPI), effectively acts as a potassium-competitive acid blocker (P-CAB) with potent antisecretory activity. It notably inhibits H+,K+-ATPase activity in porcine gastric microsomes, demonstrating an IC50 of 19 nM at pH 6.5. Primarily developed for researching acid-related diseases like gastroesophageal reflux disease and peptic ulcer disease, vonoprazan hydrochloride also serves in the eradication of Helicobacter pylori [1] [2] [3].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Vonoprazan hydrochloride, a proton pump inhibitor (PPI), effectively acts as a potassium-competitive acid blocker (P-CAB) with potent antisecretory activity. It notably inhibits H+,K+-ATPase activity in porcine gastric microsomes, demonstrating an IC50 of 19 nM at pH 6.5. Primarily developed for researching acid-related diseases like gastroesophageal reflux disease and peptic ulcer disease, vonoprazan hydrochloride also serves in the eradication of Helicobacter pylori [1] [2] [3]. |
In vitro | Vonoprazan demonstrates concentration-dependent activity on porcine gastric H+, K+-ATPase, ranging from 0.1 nM to 10 μM over 30 minutes, without affecting Na+, K+-ATPase activity, even at concentrations up to 500 times its IC 50 against gastric H+, K+-ATPase [2]. |
In vivo | Vonoprazan (1-4 mg/kg; p.o.) effectively inhibits both basal and 2-deoxy-D-glucose (200 mg/kg; s.c.)-induced gastric acid secretion in a dose-dependent manner, with complete inhibition observed at the 4 mg/kg dosage in male 7- or 8-week-old Sprague-Dawley rats [2]. This outcome suggests a proportional relationship between the administered dose of vonoprazan and its efficacy in reducing gastric acid secretion, highlighting its potential therapeutic role in conditions requiring gastric acid suppression. |
Molecular Weight | 381.85 |
Formula | C17H17ClFN3O2S |
CAS No. | 1957202-44-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Vonoprazan hydrochloride 1957202-44-6 inhibitor inhibit