Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

Adapalene

🥰Excellent
Catalog No. T1093Cas No. 106685-40-9
Alias CD271

Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.

Adapalene
Other Forms of Adapalene:

Adapalene

🥰Excellent
Purity: 99.76%
Catalog No. T1093Alias CD271Cas No. 106685-40-9
Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$30In StockIn Stock
50 mg$40In StockIn Stock
100 mg$64In StockIn Stock
500 mg$129In StockIn Stock
1 g$193-In Stock
1 mL x 10 mM (in DMSO)$39In StockIn Stock
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Batch Information

Select Batch
Purity:99.76%
Contact us for more batch information

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity
Description
Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.
Targets&IC50
RARα:22 nM (AC50), RARβ:2.3 nM (AC50), RARγ:9.3 nM (AC50)
In vitro
In rhino mice, Adapalene reduces the quantity of comedonal melanin in the epidermis and increases epidermal thickness. Within both normal skin and acne explants, Adapalene decreases the expression of TLR-2 (TLR-2) and IL-10 (IL-10). By upregulating CD1d expression and downregulating the IL-10 expression in keratinocytes, Adapalene modulates the epidermal immune system. This action enhances the interaction between dendritic cells and T lymphocytes, augmenting antimicrobial activity against Propionibacterium acnes.
In vivo
In colorectal cancer cell lines CC-531, HT-29, and LOVO, as well as in human foreskin fibroblasts, Adapalene induces caspase-3 activity in tumor cells, inhibits DNA synthesis in a time- and dose-dependent manner, and triggers apoptosis.
SynonymsCD271
Chemical Properties
Molecular Weight412.52
FormulaC28H28O3
Cas No.106685-40-9
SmilesCOC1=CC=C(C=C1C12CC3CC(CC(C3)C1)C2)C1=CC2=CC=C(C=C2C=C1)C(O)=O
Relative Density.1.233 g/cm3
Storage & Solubility Information
Storagekeep away from direct sunlight,store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 12.5 mg/mL (30.3 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 1 mg/mL (2.42 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4241 mL12.1206 mL24.2412 mL121.2062 mL
5 mM0.4848 mL2.4241 mL4.8482 mL24.2412 mL
10 mM0.2424 mL1.2121 mL2.4241 mL12.1206 mL
20 mM0.1212 mL0.6060 mL1.2121 mL6.0603 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

tumorRXRRetinoidReceptorRetinoid X receptorsRetinoid ReceptorretinoidRetinoic acid receptorsRARγRARβRARαRAR/RXRRARInhibitorinhibitGOT1CD-271CD 271AutophagyApoptosisAdapaleneacne
Related Tags: buy Adapalene | purchase Adapalene | Adapalene cost | order Adapalene | Adapalene chemical structure | Adapalene in vivo | Adapalene in vitro | Adapalene formula | Adapalene molecular weight
TargetMol | Logo

Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.