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Dithiazanine iodide

Name: Dithiazanine iodide
Brand: TargetMol
SKU: T19807
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19807Cas No. 514-73-8

Alias Vercidon, Telmide, NSC 221154, Netocyd, Delvex, Abminthic

Dithiazanine iodide (Netocyd) is a benzothiazole. It has been used as an antinematodal agent. It also has been effective as a nanoparticle in treating glioblastoma.

Dithiazanine iodide

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Purity: 99.89%

Catalog No. T19807Alias Vercidon, Telmide, NSC 221154, Netocyd, Delvex, AbminthicCas No. 514-73-8

Dithiazanine iodide (Netocyd) is a benzothiazole. It has been used as an antinematodal agent. It also has been effective as a nanoparticle in treating glioblastoma.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$46	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Appearance:Solid

Color:Green to Black

Resource Download

COA LCMS HNMR

Product Introduction

Dithiazanine iodide AI Summary

Dithiazanine iodide exhibits a high level of inhibition of Taq polymerase, achieving 91.0% inhibition at a concentration of 20 mM. However, its effect on human telomerase activity in HeLa cell extracts is significantly lower, showing less than 10.0% inhibition at a higher concentration of 50 mM carbocyanine. Additionally, Dithiazanine iodide hinders the aggregation of His-tagged human recombinant 2N4R tau protein, with an IC50 value of 2150.0 nM determined through a filter trap assay assessing octadecyl sulphate-induced fibrillation. Beyond these specific activities, Dithiazanine iodide demonstrates broad bioactivity, potent in assays involving ubiquitin-specific protease USP2a, Menin-MLL interaction, Lamin A splicing, RECQ1, JMJD2E, MLL CXXC domain-DNA interaction, mitochondrial processes, miRNAs, Rab9 promoter activation, SMN2 splice variant expression, and other cellular functions. It also inhibits enzymes such as Leishmania Mexicana Pyruvate Kinase, Tyrosyl-DNA Phosphodiesterase, Tau fibril formation, and Aldehyde Dehydrogenase 1, and displays cytotoxic effects on certain cell models. This diversity in bioactivity positions Dithiazanine iodide as a promising agent for biomedical research and potential therapeutic development..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dithiazanine iodide (Netocyd) is a benzothiazole. It has been used as an antinematodal agent. It also has been effective as a nanoparticle in treating glioblastoma.
Synonyms	Vercidon, Telmide, NSC 221154, Netocyd, Delvex, Abminthic

Chemical Properties

Molecular Weight	518.48
Formula	C₂₃H₂₃IN₂S₂
Cas No.	514-73-8
Smiles	[I-].CCN1\C(Sc2ccccc12)=C/C=C/C=C/c1sc2ccccc2[n+]1CC
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5.19 mg/mL (10.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9287 mL	9.6436 mL	19.2871 mL	96.4357 mL
5 mM	0.3857 mL	1.9287 mL	3.8574 mL	19.2871 mL
10 mM	0.1929 mL	0.9644 mL	1.9287 mL	9.6436 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc