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Anti-FOXO1 Antibody (6M554) (Synonyms: FOXO1A, Forkhead, Drosophila, homolog of, in rhabdomyosarcoma, Forkhead...)
Catalog No. TMAC-01543 Copy Product Info
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Anti-FOXO1 Antibody (6M554) is a Rabbit antibody targeting FOXO1. Anti-FOXO1 Antibody (6M554) can be used in ICC,IHC,WB.
Anti-FOXO1 Antibody (6M554)
Copy Product Info🥰Excellent
Catalog No. TMAC-01543
Synonyms FOXO1A, Forkhead, Drosophila, homolog of, in rhabdomyosarcoma, Forkhead(Drosophila) homolog 1(rhabdomyosarcoma), Forkhead in rhabdomyosarcoma, Forkhead box protein O1A, Forkhead box protein O1, Forkhead box O1, Forkhead, Fkhr1, FKHR, FKH1, FKH 1, AI876417, Afxh
Anti-FOXO1 Antibody (6M554) is a Rabbit antibody targeting FOXO1. Anti-FOXO1 Antibody (6M554) can be used in ICC,IHC,WB.
Anti-FOXO1 Antibody
(6M554)
(6M554)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $297 | 7-10 days | 7-10 days | |
| 100 μL | $496 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-FOXO1 Antibody (6M554) is a Rabbit antibody targeting FOXO1. Anti-FOXO1 Antibody (6M554) can be used in ICC,IHC,WB. |
| Synonyms | FOXO1A, Forkhead, Drosophila, homolog of, in rhabdomyosarcoma, Forkhead(Drosophila) homolog 1(rhabdomyosarcoma), Forkhead in rhabdomyosarcoma, Forkhead box protein O1A, Forkhead box protein O1, Forkhead box O1, Forkhead, Fkhr1, FKHR, FKH1, FKH 1, AI876417, Afxh |
| Ig Type | IgG |
| Clone | 6M554 |
| Reactivity | Human,Mouse,Rat,zebrafish |
| Verified Activity | 1. Western blot analysis of FOXO1A on different lysates using anti-FOXO1A antibody at 1/1,000 dilution. Positive control: Lane 1: Hela, Lane 2: NIH/3T3. 2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-FOXO1A antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-FOXO1A antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-FOXO1A antibody. Counter stained with hematoxylin. 5. Immunohistochemical analysis of paraffin-embedded mouse heart tissue using anti-FOXO1A antibody. Counter stained with hematoxylin. 6. ICC staining FOXO1A in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. ICC staining FOXO1A in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 8. ICC staining FOXO1A in NIH/3T3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.         |
| Application | |
| Recommended Dose | WB: 1:1000-2000; IHC: 1:50-200; ICC: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | FKHR (for forkhead in rhabdomyosarcoma) and FKHRL1 are members of the forkhead family of transcription factors. Transcriptional activation of FKHR proteins is regulated by the serine/threonine kinase Akt1, which phosphorylates FKHRL1 and results in FKHRL1 associating with 14-3-3 proteins and being retained in the cytoplasm. Induction of apoptosis or withdrawal of growth factors stimulates dephosphorylation and nuclear translocation of FKHR proteins, leading to FKHR-induced gene-specific transcriptional activation. FKHR, also designated forkhead box protein O1A (FOXO1), is a ubiquitously expressed protein that shuttles between the cytoplasm and nucleus. Genetic mutations in FKHR genes, including the t(2;13) and t(1;3) translocations, are commonly found in alveolar rhabdomyosarcomas. These translocations result in the fusion of the amino terminus of Pax-3 or Pax-7, including the paired box and homeodomain DNA-binding domains, with the carboxy-terminus of FKHR, which contains a transcriptional activation domain. The Pax-3/FKHR fusion protein appears to function as an oncogenic transcription factor that enhances the activation of normal Pax-3 target genes. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 80 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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