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Bax inhibitor peptide V5

Name: Bax inhibitor peptide V5
Brand: TargetMol
SKU: T10463
Rating: 4.5 (1 reviews)

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Catalog No. T10463Cas No. 579492-81-2

Alias BIP-V5, BAX Inhibiting Peptide V5

Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor exhibiting anticancer activity.

Bax inhibitor peptide V5

😃Good

Catalog No. T10463Alias BIP-V5, BAX Inhibiting Peptide V5Cas No. 579492-81-2

Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor exhibiting anticancer activity.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$87	7-10 days	7-10 days
10 mg	$126	7-10 days	7-10 days
25 mg	$267	7-10 days	7-10 days
50 mg	$443	7-10 days	7-10 days
100 mg	Inquiry	7-10 days	7-10 days
200 mg	Inquiry	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor exhibiting anticancer activity.
In vitro	Bax inhibitor peptide V5 (0-50 μM) selectively reduces cell death in STF-cMyc cells, with no significant impact on NCI-H23 or SW620 cells. It does not notably affect cell cycle arrest at the G2/M phase [1]. Furthermore, the treatment with BIPV5 leads to a substantial increase in the expression of anti-apoptotic proteins Bcl-2 and XIAP, by over 3-fold and 11-fold respectively, while concurrently decreasing the expression of pro-apoptotic proteins Bax and Bad, and the nuclear factor-κB-p65, by 10%, 30%, and nearly 50% respectively [2].
In vivo	In mice model, Bax inhibitor peptide V5 (100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation [2].
Synonyms	BIP-V5, BAX Inhibiting Peptide V5

Chemical Properties

Molecular Weight	586.79
Formula	C₂₇H₅₀N₆O₆S
Cas No.	579492-81-2
Smiles	CSCCC(NC(=O)C1CCCN1C(=O)C(N)C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(O)=O
Relative Density.	1.185 g/cm3 (Predicted)
Sequence	H-Val-Pro-Met-Leu-Lys-OH
Sequence Short	VPMLK

Storage & Solubility Information

Storage

keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (51.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (3.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7042 mL	8.5209 mL	17.0419 mL	85.2094 mL
5 mM	0.3408 mL	1.7042 mL	3.4084 mL	17.0419 mL
10 mM	0.1704 mL	0.8521 mL	1.7042 mL	8.5209 mL
20 mM	0.0852 mL	0.4260 mL	0.8521 mL	4.2605 mL
50 mM	0.0341 mL	0.1704 mL	0.3408 mL	1.7042 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc