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UoS 12258
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Catalog No. T36809Cas No. 875927-64-3
Alias UoS12258
UoS 12258 is a selective and efficient AMPA receptor positive allosteric modulator, reversing acute and subacute drug-induced deficits in rat novel object recognition, used to study cognitive disorders.
UoS 12258
🥰Excellent
Purity: 99.84%
Catalog No. T36809Alias UoS12258Cas No. 875927-64-3
UoS 12258 is a selective and efficient AMPA receptor positive allosteric modulator, reversing acute and subacute drug-induced deficits in rat novel object recognition, used to study cognitive disorders.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $47 | In Stock | In Stock | |
| 5 mg | $108 | In Stock | In Stock | |
| 10 mg | $179 | In Stock | In Stock | |
| 25 mg | $297 | In Stock | In Stock | |
| 50 mg | $453 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.84%
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Product Introduction
Bioactivity
Chemical Properties
| Description | UoS 12258 is a selective and efficient AMPA receptor positive allosteric modulator, reversing acute and subacute drug-induced deficits in rat novel object recognition, used to study cognitive disorders. |
| In vitro | UoS 12258 is a selective, positive allosteric regulator of AMPA receptors. In the natural heterooligomeric AMPA receptor in rats, UoS 12258 showed a minimum effective concentration of about 10 nM in vitro and enhanced AMPA receptor-mediated synaptic transmission at an estimated free brain concentration of about 15 nM in vivo. [1] |
| In vivo | UoS 12258 (0.03 mg/kg to 0.3 mg/kg) reversed delayed induction deficits in new object recognition in rats after acute and subchronic administration. [1] |
| Synonyms | UoS12258 |
| Molecular Weight | 334.41 |
| Formula | C17H19FN2O2S |
| Cas No. | 875927-64-3 |
| Smiles | N(S(C(C)C)(=O)=O)[C@@H]1CC=2C(C1)=CC=C(C2)C=3C=CC(F)=NC3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (299.03 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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