Shopping Cart

Your shopping cart is currently empty

PDM11

Name: PDM11
Brand: TargetMol
SKU: T5541
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T5541Cas No. 1032508-03-4

Alias PDM 11, 1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth

PDM11 (1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth) is an antagonist of aryl hydrocarbon receptor (AhR)

PDM11

Copy Product Info

😃Good

Purity: 99.88%

Catalog No. T5541Alias PDM 11, 1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMethCas No. 1032508-03-4

PDM11 (1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth) is an antagonist of aryl hydrocarbon receptor (AhR)

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$35	In Stock	In Stock
25 mg	$73	In Stock	In Stock
50 mg	$118	In Stock	In Stock
100 mg	$189	In Stock	In Stock
200 mg	$278	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

PDM11 AI Summary

PDM11 exhibits bioactivity by inhibiting human aromatase with an inhibition rate of 14.65% at a concentration of 20 µg/ml. The inhibitory assay protocol included a preincubation with NADP+ for 10 minutes before substrate addition, with measurements taken 30 minutes after the addition. Additionally, PDM11 shows cytotoxicity against human HT-29 and Caco-2 cells after 3 days, as evidenced by [3H]thymidine incorporation assay, with an IC50 value greater than 10000.0 nM for both cell lines..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	PDM11 (1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth) is an antagonist of aryl hydrocarbon receptor (AhR)
Targets&IC50	BRD4(2):33 nM , BRD4(1):77 nM
Synonyms	PDM 11, 1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth

Chemical Properties

Molecular Weight	274.74
Formula	C₁₆H₁₅ClO₂
Cas No.	1032508-03-4
Smiles	C(=C/C1=CC=C(Cl)C=C1)\C2=CC(OC)=CC(OC)=C2
Relative Density.	1.181 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (36.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 1 mg/mL (3.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6398 mL	18.1990 mL	36.3980 mL	181.9902 mL
5 mM	0.7280 mL	3.6398 mL	7.2796 mL	36.3980 mL
10 mM	0.3640 mL	1.8199 mL	3.6398 mL	18.1990 mL
20 mM	0.1820 mL	0.9100 mL	1.8199 mL	9.0995 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc