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MARK4 inhibitor 1
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Catalog No. T11947Cas No. 2271081-58-2
MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM.
MARK4 inhibitor 1
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Purity: 97.7%
Catalog No. T11947Cas No. 2271081-58-2
MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $115 | In Stock | In Stock | |
| 5 mg | $272 | In Stock | In Stock | |
| 10 mg | $396 | In Stock | In Stock | |
| 25 mg | $665 | In Stock | In Stock | |
| 50 mg | $947 | In Stock | In Stock | |
| 100 mg | $1,280 | In Stock | In Stock | |
| 200 mg | $1,720 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:97.7%
Appearance:Solid
Color:Yellow
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Product Introduction
MARK4 inhibitor 1 AI Summary
MARK4 inhibitor 1 exhibits a range of bioactivities that highlight its potential as an anticancer agent. It demonstrates inhibition of human recombinant MARK4 activity with an IC50 value of 1540 nM and shows a strong binding affinity to human recombinant MARK4 with a Ka value of 6.0 x 10^7/M. Additionally, it binds to human serum albumin (HSA) with a Ka value of 1.27 x 10^4/M. The compound has notable antiproliferative effects against various cancer cell lines including MCF7, MDA-MB-435S, HepG2, and HEK293, with IC50 values ranging from 6220 nM to 200000 nM. It induces apoptosis in these cell lines, as evidenced by flow cytometric analysis using Annexin V-FITC/propidium iodide staining. MARK4 inhibitor 1 also inhibits the growth of several cancer cell lines at a concentration of 10 µM after 48 hours, showing variable inhibition percentages relative to control cells. Overall, MARK4 inhibitor 1 displays promising bioactivities by inhibiting cell growth, inducing apoptosis, and interacting with key molecular targets..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM. |
| Targets&IC50 | MARK4:1.54 μM |
| Molecular Weight | 390.4 |
| Formula | C20H18N6O3 |
| Cas No. | 2271081-58-2 |
| Smiles | COc1ccc(Cn2cc(nn2)C(=O)N\N=C2\C(=O)Nc3c2cccc3C)cc1 |
| Relative Density. | 1.42 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Slightly soluble  |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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