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STAT3 degrader-2

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Catalog No. T78983Cas No. 2497583-03-4

STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and various diseases [1].

STAT3 degrader-2

STAT3 degrader-2

😃Good
Catalog No. T78983Cas No. 2497583-03-4
STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and various diseases [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mgInquiry8-10 weeks8-10 weeks
5 mgInquiry8-10 weeks8-10 weeks
10 mgInquiry8-10 weeks8-10 weeks
25 mgInquiry8-10 weeks8-10 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and various diseases [1].
In vitro
STAT3 degrader-2 (Compound 92) significantly reduces total STAT3 protein levels in acute leukemia Molm-16 cells after 3 hours of treatment at various concentrations (0.2 μM, 1 μM, 30 nM, 100 nM, 300 nM) [1].
In vivo
STAT3 degrader-2 (Compound 92), administered intravenously at 50 mg/kg at 6, 24, and 48-hour intervals, reduced total STAT3 protein and phosphorylated STAT3 (Y705) levels in the Molm-16 acute leukemia tumor model and SU-DHL-1 mouse tumors [1]. Additionally, it demonstrated antitumor activity against Molm-16 xenograft tumors in mice when administered intravenously once weekly (qw) at 25 and 50 mg/kg [1].
Chemical Properties
Molecular Weight1136.15
FormulaC59H62N9O13P
Cas No.2497583-03-4
SmilesC(#CCCCCCC(=O)N1C[C@H](NC(=O)C2=CC=3C(N2)=CC=C(C(P(=O)(O)O)=O)C3)C(=O)N4[C@@](CC1)(CC[C@H]4C(N[C@H](C(NC(C5=CC=CC=C5)C6=CC=CC=C6)=O)CCC(N)=O)=O)[H])C7=C8C(C(=O)N(C8)C9C(=O)NC(=O)CC9)=CC=C7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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