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STAT3 degrader-2
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Catalog No. T78983Cas No. 2497583-03-4
STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and various diseases [1].
STAT3 degrader-2
😃Good
Catalog No. T78983Cas No. 2497583-03-4
STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and various diseases [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | 8-10 weeks | 8-10 weeks | |
| 5 mg | Inquiry | 8-10 weeks | 8-10 weeks | |
| 10 mg | Inquiry | 8-10 weeks | 8-10 weeks | |
| 25 mg | Inquiry | 8-10 weeks | 8-10 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and various diseases [1]. |
| In vitro | STAT3 degrader-2 (Compound 92) significantly reduces total STAT3 protein levels in acute leukemia Molm-16 cells after 3 hours of treatment at various concentrations (0.2 μM, 1 μM, 30 nM, 100 nM, 300 nM) [1]. |
| In vivo | STAT3 degrader-2 (Compound 92), administered intravenously at 50 mg/kg at 6, 24, and 48-hour intervals, reduced total STAT3 protein and phosphorylated STAT3 (Y705) levels in the Molm-16 acute leukemia tumor model and SU-DHL-1 mouse tumors [1]. Additionally, it demonstrated antitumor activity against Molm-16 xenograft tumors in mice when administered intravenously once weekly (qw) at 25 and 50 mg/kg [1]. |
| Molecular Weight | 1136.15 |
| Formula | C59H62N9O13P |
| Cas No. | 2497583-03-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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