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SD-91

Name: SD-91
Brand: TargetMol
SKU: T78983
Price: 4620 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: STAT3 degrader-2, SD 91) Copy Product Info

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Synonyms: STAT3 degrader-2, SD 91

Catalog No. T78983 Copy Product Info

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SD-91 is a PROTAC-based compound that effectively reduces total STAT3 protein levels. STAT3 Degrader-2 is utilized in research involving cancer and multiple disease-associated STAT3 signaling pathways. SD-91 is particularly valuable for investigations involving targeted protein degradation, transcription factor regulation, and oncogenic signaling modulation.

Cas No. 2497583-03-4

Pack Size	Price	USA Stock	Global Stock
25 mg	$4,620	-	In Stock
50 mg	$5,880	-	In Stock
100 mg	$8,000	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	SD-91 is a PROTAC-based compound that effectively reduces total STAT3 protein levels. STAT3 Degrader-2 is utilized in research involving cancer and multiple disease-associated STAT3 signaling pathways. SD-91 is particularly valuable for investigations involving targeted protein degradation, transcription factor regulation, and oncogenic signaling modulation.
Targets & IC50	STAT3:28nM(Kd), STAT3:5.5nM(Ki)
In vitro	SD-91 significantly reduces total STAT3 protein levels in acute leukemia Molm-16 cells after 3 hours of treatment at various concentrations (0.2 μM, 1 μM, 30 nM, 100 nM, 300 nM)[1].
In vivo	SD-91 (50 mg/kg; i.v.; 6 h, 24 h, 48 h) reduces total STAT3 protein and phosphorylated STAT3 (Y705) levels in the Molm-16 acute leukemia tumor model and SU-DHL-1 mouse tumors[1]. SD-91 (25，50 mg/kg；i.v.) demonstrats antitumor activity against Molm-16 xenograft tumors in mice when administered intravenously once weekly (qw) at 25 and 50 mg/kg[1].
Synonyms	STAT3 degrader-2, SD 91

Chemical Properties

Molecular Weight	1136.15
Formula	C₅₉H₆₂N₉O₁₃P
Cas No.	2497583-03-4
Smiles	C(#CCCCCCC(=O)N1C[C@H](NC(=O)C2=CC=3C(N2)=CC=C(C(P(=O)(O)O)=O)C3)C(=O)N4[C@@](CC1)(CC[C@H]4C(N[C@H](C(NC(C5=CC=CC=C5)C6=CC=CC=C6)=O)CCC(N)=O)=O)[H])C7=C8C(C(=O)N(C8)C9C(=O)NC(=O)CC9)=CC=C7

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (70.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8802 mL	4.4008 mL	8.8017 mL	44.0083 mL
5 mM	0.1760 mL	0.8802 mL	1.7603 mL	8.8017 mL
10 mM	0.0880 mL	0.4401 mL	0.8802 mL	4.4008 mL
20 mM	0.0440 mL	0.2200 mL	0.4401 mL	2.2004 mL
50 mM	0.0176 mL	0.0880 mL	0.1760 mL	0.8802 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: SD-91 chemical structure | SD-91 in vivo | SD-91 in vitro | SD-91 formula | SD-91 molecular weight