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Licostinel (Synonyms: CGP-63446, CGP 63446, ACEA-1021, ACEA1021, ACEA 1021)
Catalog No. T27828 Copy Product Info
Purity: 98.02%
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Licostinel (CGP 63446) is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.
Licostinel
Copy Product Info😃Good
Catalog No. T27828
Synonyms CGP-63446, CGP 63446, ACEA-1021, ACEA1021, ACEA 1021
Licostinel (CGP 63446) is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.
Cas No. 153504-81-5
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 mg | $33 | In Stock | In Stock | |
| 10 mg | $52 | In Stock | In Stock | |
| 25 mg | $110 | In Stock | In Stock | |
| 50 mg | $178 | In Stock | In Stock | |
| 100 mg | $266 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $35 | In Stock | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:98.02%
Appearance:Solid
Color:Yellow
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Product Introduction
Licostinel AI Summary
Licostinel exhibits a range of pharmacological effects and binding affinities. It shows a high affinity for the glycine binding site of the NMDA receptor, with IC50 values ranging from 1.4 nM to 5.9 nM in various assays. It demonstrates potent anticonvulsant activity, indicated by an effective dose of 3.3 mg/kg in protecting DBA/2 mice from audiogenic seizures, and an ED50 of 4.0 mg/kg in the mouse maximal electroshock (MES) assay. The compound also shows effectiveness in reducing nociception in vivo, with an ED50 of 5.0 mg/kg and an EC50 of 1000.0 nM in a formalin paw nociception model. Furthermore, it exhibits selectivity for the NMDA receptor glycine site over non-NMDA receptor sites and has a moderate binding affinity (Kb = 1500.0 nM) for the AMPA receptor. Licostinel has a partition coefficient (logP) of 0.21, suggesting good water solubility and favorable pharmacokinetic properties. Additionally, it has been shown to reduce infarct volumes in rat models of cerebral ischemia and inhibit glutamate-stimulated cyclic GMP accumulation in neonatal rat cerebral slices..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Licostinel (CGP 63446) is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia. |
| Synonyms | CGP-63446, CGP 63446, ACEA-1021, ACEA1021, ACEA 1021 |
| Molecular Weight | 276.03 |
| Formula | C8H3Cl2N3O4 |
| Cas No. | 153504-81-5 |
| Smiles | [O-][N+](=O)c1c(Cl)c(Cl)cc2[nH]c(=O)c(=O)[nH]c12 |
| Relative Density. | 1.757g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (199.25 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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