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VEGF121 Protein, Human, Recombinant (E. coli)

Catalog No. TMPS-00168

VEGF121 Protein, Human, Recombinant (E. coli) is expressed in E. coli. The accession number is P15692-9.

VEGF121 Protein, Human, Recombinant (E. coli)

VEGF121 Protein, Human, Recombinant (E. coli)

Catalog No. TMPS-00168
VEGF121 Protein, Human, Recombinant (E. coli) is expressed in E. coli. The accession number is P15692-9.
Pack SizePriceAvailabilityQuantity
10 μg $1707-10 days
50 μg $6227-10 days
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Product Information

Biological Activity
ED 50 < 5.0 ng/ml, measured by a cell proliferation assay using HUVEC Cells, corresponding to a specific activity of > 2.0 × 10 5 units/mg.
Description
VEGF121 Protein, Human, Recombinant (E. coli) is expressed in E. coli. The accession number is P15692-9.
Species
Human
Expression System
E. coli
TagTag Free
Accession NumberP15692-9
Synonyms
VPF,VEGF-121,Vascular Permeability Factor,Vascular Endothelial Growth Factor 121
Construction
Pro28-Arg147
Protein Purity
> 95% as determined by SDS-PAGE; > 95% as determined by HPLC
Molecular Weight~28.2 kDa (Non-reducing conditions)
Endotoxin< 0.2 EU/μg of protein as determined by the LAL method.
FormulationLyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution
Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
ShippingIn general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background
VEGF-A121 is one of five isoforms (121, 145, 165, 189, and 206) of VEGF protein, a cytokine belonging to the Platelet Differentiation Growth Factor (PDGF) family, and existing as a disulfide-linked homodimeric glycoprotein. In contrast to the longer isoforms, VEGF-A121 is more freely diffusible, and cannot bind to heparin. In vivo, VEGF is expressed predominantly in lung, heart, kidney, and adrenal glands, and the expression of VEGF is up-regulated by a number of growth factors, including PDGF, Fibroblast Growth Factor (FGF), Epidermal Growth Factor (EGF), and Tumor Necrosis Factor (TNF). VEGF signals via binding to two tyrosine kinase receptors: the Fms-like tyrosine kinase 1 (Flt-1) and the kinase domain receptor (KDR). VEGF is a specific mitogen and survival factor, contributing to abnormal angiogenesis and cancer development.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Tech Support

Please read the User Guide of Recombinant Proteins for more specific information.