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Melittin Acetate

Catalog No. TP1299L1

Synonyms: Melittin Acetate(20449-79-0 Free base), Forapin Acetate

Melittin Acetate (Forapin Acetate) is a PLA2 activator. Melittin Acetate stimulates the activity of the low molecular weight PLA2, while it does not increase the activity of the high molecular weight PLA2.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Melittin Acetate, CAS N/A

Pack Size	Availability	Price/USD
1 mg	In stock	$ 67.00
5 mg	In stock	$ 137.00
10 mg	In stock	$ 239.00
25 mg	In stock	$ 473.00
50 mg	In stock	$ 618.00
100 mg	In stock	$ 927.00
500 mg	In stock	$ 1,870.00

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Purity: 99.78%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

Melittin Acetate is an immunologically related PLA2 stimulating peptide from bee venom. Melittin Acetate increases the activity of the high molecular weight enzyme[1]. Melittin Acetate is a cytotoxic peptide from bee venom. Melittin Acetate shows toxicity against both A2780CR and A2780 cells, with IC50 values of 4.5 and 6.8 μg/mL, respectively. Melittin Acetate shows natural anti-bacterial, anti-viral, and anti-inflammatory properties. It has also been shown to have diverse anticancer effects in several different cancer cell lines including those of gastric, breast, ovarian, liver, prostate, cervical, and lung origins. The mechanisms by which Melittin Acetate, an amphipathic haemolytic peptide, exerts its potential anticancer effects include inhibition of cell proliferation, induction of apoptosis, and direct necrosis. Melittin Acetate can also prevent EGF-induced cell invasion through its inhibition of the PI3K/Akt/mTOR signaling pathway, but this is primarily related to breast cancer cells[2].

Synonyms	Melittin Acetate(20449-79-0 Free base), Forapin Acetate
Molecular Weight	2906.51
Formula	C133H233N39O33

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Steiner MR, et al. Responses of purified phospholipases A2 to phospholipase A2 activating protein (PLAP) and Melittin. Biochim Biophys Acta. 1993 Feb 10;1166(1):124-30. 2. Alonezi S, et al. Metabolomic Profiling of the Effects of Melittin on Cisplatin Resistant and Cisplatin Sensitive Ovarian Cancer Cells Using Mass Spectrometry and Biolog Microarray Technology. Metabolites. 2016 Oct 13;6(4). pii: E35.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library

Related Products

Related compounds with same targets

Atg4B-IN-2 nSMase2-IN-1 Halopemide Lp-PLA2-IN-14 VU0285655-1 Halobetasol propionate Vinaxanthone A4333

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Melittin Acetate Metabolism Phospholipase Melittin Acetate(20449-79-0 Free base) Forapin Acetate inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.