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Cell Cycle/Checkpoint

Nucleoside Antimetabolite/Analog

Serine/threonin kinase

Metabolism

Acetyl-CoA Carboxylase

Amino Acids and Derivatives

Angiotensin-converting Enzyme (ACE)

Endogenous Metabolite

Glutathione Peroxidase

(43)

Glyoxalase

(2)

HIF/HIF Prolyl-Hydroxylase

Indoleamine 2,3-Dioxygenase (IDO)

(36)

Isocitrate Dehydrogenase (IDH)

Mitochondrial Metabolism

(102)

N-Acetylglucosaminyltransferase

Procollagen C Proteinase

(1)

Prolyl Endopeptidase (PREP)

Reactive Oxygen Species

Serine/threonin kinase

(47)

Stearoyl-CoA Desaturase (SCD)

Serine/threonin kinase

Serine threonine kinase belongs to protein kinase, which can phosphorylate the OH group of serine or threonine residues. Serine threonine kinases contain Rho kinase, Aurora kinase, AMP kinase, RAF kinase, Polo like kinase, PIM kinase, ATM kinase and other kinases. The cAMP/cGMP, Ca2+/calmodulin and diacylglycerol and multiple chenmical signals can regulate the activity of serine threonine kinases.

Filter HomeSignaling PathwaysCell Cycle/Checkpoint-MetabolismSerine/threonin kinase

Wortmannin

T628319545-26-7

Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8 48 nM) that blocks autophagy.

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Camostat mesylate

T239159721-29-8

Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.

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Piceatannol

T061010083-24-6

Piceatannol (Astringenin) is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is synthetic from the conversion of resveratrol by cytochrome P450 1B1.

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Upamostat

T13257590368-25-5

Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.

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(+)-Isocorydine hydrochloride

T429113552-72-2

(+)-Isocorydine hydrochloride (Isocorydine HCl) is a eukaryote protein kinases Inhibitor.

$115

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R-IMPP

T40582133832-83-2

R-IMPP is an inhibitor of PCSK9 translation. R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin.

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HA-1004

T2752591742-10-8In house

HA-1004 is a inhibitor of PKG, PKA, PKC and MLC.

$195

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HTH-01-091

T241522000209-42-5In house

HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM) that also inhibits PIM1 2 3, RIPK2, DYRK3, smMLCK, and CLK2. It can be used to study breast cancer.

$296

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Fasudil

T1606103745-39-7

Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.

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BMT-124110 Formate

T10572L In house

BMT-124110 Formate is a selective AAK1 inhibitor (IC50: 0.9 nM) with anti-injury sensory activity.BMT-124110 Formate inhibits the BMP-2-inducible protein kinase BIKE with an IC50: 17 nM.BMT-124110 Formate inhibits the cell-cycle protein G-related BMT-124110 Formate inhibits the cell cycle protein G-associated kinase GAK with an IC50:99 nM.

$195

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Fasudil hydrochloride

T3060105628-07-7

Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.

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ML-7 hydrochloride

T3050110448-33-4

ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-muscle myosin light chain kinase, PKA, and PKC.

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N-Cyclohexyl-4-[1-(1-piperazinyl)-2,6-naphthyridin-3-yl]-2-pyridinamine

T92561071135-06-2

N-Cyclohexyl-4-[1-(1-piperazinyl)-2,6-naphthyridin-3-yl]-2-pyridinamine is a novel 2,6-naphthyridine identified by high throughput screen (HTS) as a dual protein kinase C D (PKC PKD) inhibitor[1].

$148

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SBC-110736

T45241629166-02-4

SBC-110736 is an inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9).

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SRPIN340

T1954218156-96-8

SRPIN340 (SRPK inhibitor), a serine arginine-rich protein kinase (SRPK)-specific inhibitor, is potent for SRPK1 (IC50 = 0.89 uM).

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cid755673

T2458521937-07-5

CID755673 is an effective and specific cell-active inhibitor for PKD (IC50: 182 nM); exhibits selective PKD1 inhibition when compared with PLK1, AKT, CAMKIIα, CAK, and PKC isoforms.

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SBC-115076

T2626489415-96-5

SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.

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WNK-IN-11

T54562123489-30-3

WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)

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SPHINX31

T51941818389-84-2

SPHINX31 is a potent inhibitor of serine arginine-rich protein kinase 1 (SRPK1; IC50: 5.9 nM).

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WNK463

T70172012607-27-9

WNK463 is a pan-WNK-kinase inhibitor. It effectively inhibits the in vitro kinase activity of all four WNK family members (WNK1 2 3 4).

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Chymotrypsin

T735949004-07-3

Chymotrypsin (Chymotrypsin A) is a serine protease synthesized by the pancreas, which cleaves protein chains on the carboxyl side of aromatic amino acids.

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1-NM-PP1

T2153221244-14-0

1-NM-PP1 (PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.

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IPR-803

T11666892243-35-5

IPR-803 is an effective inhibitor of the uPAR·uPA protein-protein interaction (PPI) with anti-tumor activity. IPR-803 binds directly to uPAR with a Ki of 0.2 μM.

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PCSK9-IN-10

T72025368434-98-4

PCSK9-IN-10, a potent and orally active inhibitor of Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9), exhibits a half-maximal inhibitory concentration (IC50) of 6.4 µM. By enhancing the expression of Low-Density Lipoprotein Receptor (LDLR) protein and reducing PCSK9 expression, PCSK9-IN-10 effectively decreases atherosclerosis progression. This compound holds promise for hyperlipidemia research applications.

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