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Carbacyclin

Name: Carbacyclin
Brand: TargetMol
SKU: T10673
Rating: 4.5 (1 reviews)

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Catalog No. T10673Cas No. 69552-46-1

Alias Carbaprostacyclin, Carba-PGI2

Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation.

Carbacyclin

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Catalog No. T10673Alias Carbaprostacyclin, Carba-PGI2Cas No. 69552-46-1

Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 μg	$337	35 days	35 days
500 μg	$555	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation.
In vitro	Carbacyclin acts as an inhibitor of platelet aggregation induced by ADP or collagen in vitro[2]. It also enhances CPT-1 mRNA expression through PPARδ, independent of the IP receptor signaling pathway. Furthermore, Carbacyclin, within the concentration range of 0.02 μM to 20 μM, activates the IP receptor signaling pathway through PKA, an effect that is blocked by H-89, a PKA inhibitor. Additionally, Carbacyclin, at concentrations ranging from 0.02 to 80 μM, increases PPRE promoter activity via PPARδ in cardiomyocytes, again independent of the IP receptor pathway[3].
In vivo	Carbacyclin exhibits 0.03 times the activity of prostacyclin in inhibiting platelet aggregation in human, rabbit, or dog plasma [2]. Additionally, in the murine heart, Carbacyclin (100 μg, i.p.) induces CPT-1 mRNA expression [3].
Synonyms	Carbaprostacyclin, Carba-PGI2

Chemical Properties

Molecular Weight	350.49
Formula	C₂₁H₃₄O₄
Cas No.	69552-46-1
Smiles	C(=C/[C@H](CCCCC)O)\[C@@H]1[C@@]2([C@@](C/C(=C\CCCC(O)=O)/C2)(C[C@H]1O)[H])[H]
Relative Density.	1.177 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc