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MW-150 hydrochloride

Catalog No. T39343 CAS 1923773-01-6

Synonyms: MW01-18-150SRM hydrochloride, MW-150 hydrochloride

MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a potent and selective inhibitor of p38α MAPK, with a Ki value of 101 nM. It exhibits excellent CNS penetration and oral bioavailability. MW-150 hydrochloride (MW01-18-150SRM hydrochloride) effectively suppresses the phosphorylation of MK2, a substrate of endogenous p38α MAPK, in activated glial cells.

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MW-150 hydrochloride, CAS 1923773-01-6

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Description	MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a potent and selective inhibitor of p38α MAPK, with a Ki value of 101 nM. It exhibits excellent CNS penetration and oral bioavailability. MW-150 hydrochloride (MW01-18-150SRM hydrochloride) effectively suppresses the phosphorylation of MK2, a substrate of endogenous p38α MAPK, in activated glial cells.
Targets&IC50	p38α:101 nM (Ki)
In vitro	MW-150 hydrochloride (MW01-18-150SRM hydrochloride) demonstrates concentration-dependent inhibition of p38αMAPK's phosphorylation of the endogenous substrate MK2 in activated glia, alongside blocking the heightened production of IL-1β by the same cells. The IC50 values for this inhibitory activity on MK2 and IL-1β are 332 nM and 936 nM, respectively[1].
In vivo	Administering MW-150 hydrochloride (MW01-18-150SRM hydrochloride) at a dosage of 2.5 mg/kg orally each day for 3-4 months significantly enhances cognitive performance in APP/PS1 transgenic (Tg) mice, as evidenced in radial arm water maze (RAWM) and contextual fear conditioning tests. Similarly, a 14-day intraperitoneal (i.p.) treatment of the same dosage in APP NLh/NLh × PS P264L/P264L knock-in mice, which do not overexpress the amyloid precursor protein, results in RAWM performance comparable to that of wild-type (WT) mice. These findings suggest that MW-150 hydrochloride can ameliorate cognitive deficits in mouse models of amyloid-beta overexpression.

Synonyms	MW01-18-150SRM hydrochloride, MW-150 hydrochloride
Molecular Weight	417.94
Formula	C24H24ClN5
CAS No.	1923773-01-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Roy SM, et al. Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. ACS Chem Neurosci. 2015 Apr 15;6(4):666-80.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MW-150 hydrochloride 1923773-01-6 MW150 hydrochloride MW01-18-150SRM hydrochloride MW150 Hydrochloride MW 150 Hydrochloride MW01-18-150SRM Hydrochloride MW 150 hydrochloride MW-150 Hydrochloride inhibitor inhibit

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