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CHRNA5 Protein, Human, Recombinant (His)

Catalog No. TMPY-04321
Synonyms: cholinergic receptor, nicotinic, α5 (neuronal), cholinergic receptor, nicotinic, alpha 5 (neuronal), LNCR2

Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in smoking-related diseases such as chronic obstructive pulmonary disease (COPD), peripheral artery disease and lung cancer. CHRNA5 may influence susceptibility to lung cancer among Han smokers. Genetic variation in nicotinic receptor alpha 5 (CHRNA5) has been associated with increased risk of addiction-associated phenotypes in humans.

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CHRNA5 Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
100 μg 5 days $ 700.00
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Biological Description
Technical Params
Product Properties
Description Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in smoking-related diseases such as chronic obstructive pulmonary disease (COPD), peripheral artery disease and lung cancer. CHRNA5 may influence susceptibility to lung cancer among Han smokers. Genetic variation in nicotinic receptor alpha 5 (CHRNA5) has been associated with increased risk of addiction-associated phenotypes in humans.
Species Human
Expression System HEK293
Tag His
Accession Number P30532
Synonyms cholinergic receptor, nicotinic, α5 (neuronal), cholinergic receptor, nicotinic, alpha 5 (neuronal), LNCR2
Construction A DNA sequence encoding the human CHRNA5 (NP_000736.2) (Met1-Thr254) was expressed with a polyhistidine tag at the C-terminus.
Protein Purity > 90 % as determined by SDS-PAGE.
Molecular Weight Approxiamtely 28 kDa
Endotoxin < 1.0 EU per μg protein as determined by the LAL method.
Formulation Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Research Background Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in smoking-related diseases such as chronic obstructive pulmonary disease (COPD), peripheral artery disease and lung cancer. CHRNA5 may influence susceptibility to lung cancer among Han smokers. Genetic variation in nicotinic receptor alpha 5 (CHRNA5) has been associated with increased risk of addiction-associated phenotypes in humans.

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Keywords

CHRNA5 Protein, Human, Recombinant (His) cholinergic receptor, nicotinic, a 5 LNCR 2 cholinergic receptor, nicotinic, alpha 5 LNCR-2 neuronal cholinergic receptor, nicotinic, α5 (neuronal) cholinergic receptor, nicotinic, α 5 cholinergic receptor, nicotinic, alpha 5 (neuronal) LNCR2 recombinant recombinant-proteins proteins protein

 

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