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STING agonist-12

Name: STING agonist-12
Brand: TargetMol
SKU: T9853
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9853Cas No. 2259624-71-8

STING agonist-12 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint consistent with STING activation.

STING agonist-12

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Purity: 98.29%

Catalog No. T9853Cas No. 2259624-71-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	In Stock	In Stock
5 mg	$80	In Stock	In Stock
10 mg	$126	In Stock	In Stock
25 mg	$263	In Stock	In Stock
50 mg	$422	In Stock	In Stock
100 mg	$628	In Stock	In Stock
200 mg	$893	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$88	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.29%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

STING agonist-12 AI Summary

STING agonist-12 activates wild-type human STING and its various mutant versions, leading to the activation of the IRF3 reporter with an EC50 value of 185.0 nM. It also shows inhibitory activity against human ERG. In BALB/c mice, the compound demonstrates significant bioavailability and pharmacokinetic properties, including relatively high oral bioavailability and favorable distribution characteristics..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	STING agonist-12 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint consistent with STING activation.
Targets&IC50	STING:185 nM (EC50)

Chemical Properties

Molecular Weight	490.88
Formula	C₂₅H₁₉ClF₄N₂O₂
Cas No.	2259624-71-8
Smiles	CC1(C)C(=O)N(Cc2c(F)cccc2Cl)c2cc(ccc12)C(=O)NCc1c(F)cc(F)cc1F
Relative Density.	1.392 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (122.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0372 mL	10.1858 mL	20.3716 mL	101.8579 mL
5 mM	0.4074 mL	2.0372 mL	4.0743 mL	20.3716 mL
10 mM	0.2037 mL	1.0186 mL	2.0372 mL	10.1858 mL
20 mM	0.1019 mL	0.5093 mL	1.0186 mL	5.0929 mL
50 mM	0.0407 mL	0.2037 mL	0.4074 mL	2.0372 mL
100 mM	0.0204 mL	0.1019 mL	0.2037 mL	1.0186 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc