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N3-C3-NHS ester

Name: N3-C3-NHS ester
Brand: TargetMol
SKU: T18466
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T18466Cas No. 943858-70-6

N3-C3-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

N3-C3-NHS ester

🥰Excellent

Purity: 99.92%

Catalog No. T18466Cas No. 943858-70-6

N3-C3-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Pack Size	Price	Availability
10 mg	$50	In Stock
25 mg	$76	In Stock
50 mg	$97	In Stock
100 mg	$162	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Batch Information

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Purity:99.92%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

N3-C3-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Chemical Properties

Molecular Weight	226.19
Formula	C₈H₁₀N₄O₄
Cas No.	943858-70-6
Smiles	[N-]=[N+]=NCCCC(=O)ON1C(=O)CCC1=O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (442.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4211 mL	22.1053 mL	44.2106 mL	221.0531 mL
5 mM	0.8842 mL	4.4211 mL	8.8421 mL	44.2106 mL
10 mM	0.4421 mL	2.2105 mL	4.4211 mL	22.1053 mL
20 mM	0.2211 mL	1.1053 mL	2.2105 mL	11.0527 mL
50 mM	0.0884 mL	0.4421 mL	0.8842 mL	4.4211 mL
100 mM	0.0442 mL	0.2211 mL	0.4421 mL	2.2105 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc