IL-18BP Protein, Mouse, Recombinant (His)

Name: IL-18BP Protein, Mouse, Recombinant (His)
Brand: TargetMol
SKU: TMPY-01111
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: MC54L, interleukin 18 binding protein, IL-18BP, Igifbp) Copy Product Info

Synonyms: MC54L, interleukin 18 binding protein, IL-18BP, Igifbp

Catalog No. TMPY-01111 Copy Product Info

IL-18BP Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19.4 kDa and the accession number is Q9Z0M9.

Pack Size	Price	USA Stock	Global Stock
5 µg	$34	-	In Stock
10 µg	$50	-	In Stock
20 µg	$79	-	In Stock
50 µg	$148	-	In Stock
100 µg	$245	-	In Stock
200 µg	$435	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:SDS-PAGE: 97.1%; SEC-HPLC: 96.9%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Information

Bioactivity

Bioactivity	Measured by its binding ability in a functional ELISA. Immobilized IL18BP Protein, Mouse, (His Tag) at 2 μg/mL (100 μL/well) can bind IL-18 Protein, Mouse Biotinylated, the EC50 of Biotinylated Mouse IL-18 is 25-80 μg/mL.
Description	IL-18BP Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19.4 kDa and the accession number is Q9Z0M9.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q9Z0M9
Construction	A DNA sequence encoding mouse IL18BP (NP_034661.1) (Met 1-Ala 193) precursor was expressed with the polyhistide tag at the C-terminus. Predicted N terminal: Thr 29
Protein Purity	> 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	MC54L, interleukin 18 binding protein, IL-18BP, Igifbp
Research Background	Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.

Chemical Properties

Molecular Weight

19.4 kDa (predicted); 35-50 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.