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CBR1 Protein, Human, Recombinant (His)

Catalog No. TMPH-01040
Synonyms: 20-beta-hydroxysteroid dehydrogenase, Carbonyl reductase [NADPH] 1, NADPH-dependent carbonyl reductase 1, CBR1, PG-9-KR, 15-hydroxyprostaglandin dehydrogenase [NADP(+)], CBR, Alcohol dehydrogenase [NAD(P)+] CBR1, SDR21C1, CRN, Prostaglandin 9-ketoreductase

NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CBR1 Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
20 μg 20 days $ 231.00
100 μg 20 days $ 437.00
500 μg 20 days $ 1,210.00
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Biological Description
Technical Params
Product Properties
Description NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
Species Human
Expression System Yeast
Tag N-terminal 6xHis-tagged
Accession Number P16152
Synonyms 20-beta-hydroxysteroid dehydrogenase, Carbonyl reductase [NADPH] 1, NADPH-dependent carbonyl reductase 1, CBR1, PG-9-KR, 15-hydroxyprostaglandin dehydrogenase [NADP(+)], CBR, Alcohol dehydrogenase [NAD(P)+] CBR1, SDR21C1, CRN, Prostaglandin 9-ketoreductase
Amino Acid SSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Construction 2-277 aa
Protein Purity > 90% as determined by SDS-PAGE.
Molecular Weight 32.2 kDa (predicted)
Formulation Tris-based buffer,50% glycerol
Reconstitution A hardcopy of COA with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage

Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.

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Keywords

CBR1 Protein, Human, Recombinant (His) 20-beta-hydroxysteroid dehydrogenase Carbonyl reductase [NADPH] 1 NADPH-dependent carbonyl reductase 1 CBR1 PG-9-KR 15-hydroxyprostaglandin dehydrogenase [NADP(+)] CBR Alcohol dehydrogenase [NAD(P)+] CBR1 SDR21C1 CRN Prostaglandin 9-ketoreductase recombinant recombinant-proteins proteins protein

 

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