Powder: -20°C for 3 years | In solvent: -80°C for 1 year
COX-2/15-LOX-IN-4 (compound 5i) is a dual inhibitor with IC50 values of 0.075 μM for COX-2 and 1.97 μM for 15-LOX. It inhibits LPS-induced production of pro-inflammatory cytokines (IL-6, ROS) and exhibits targeted anti-inflammatory effects [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | COX-2/15-LOX-IN-4 (compound 5i) is a dual inhibitor with IC50 values of 0.075 μM for COX-2 and 1.97 μM for 15-LOX. It inhibits LPS-induced production of pro-inflammatory cytokines (IL-6, ROS) and exhibits targeted anti-inflammatory effects [1]. |
In vitro | Compound 5i (COX-2/15-LOX-IN-4) reduces LPS-induced IL-6 and ROS pro-inflammatory cytokine production in the RAW 264.7 macrophage cell line, exhibiting half-maximal inhibitory concentrations (IC50s) of 7.48 μM for IL-6 and 37.54 μM for ROS, respectively [1]. |
Molecular Weight | 405.49 |
Formula | C23H20FN3OS |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
COX-2/15-LOX-IN-4 Metabolism Lipoxygenase inhibitor inhibit