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PF-06840003

Name: PF-06840003
Brand: TargetMol
SKU: T4307
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4307Cas No. 198474-05-4

Alias PF 06840003, EOS200271

PF-06840003 (EOS200271) is a specific and orally active IDO-1 inhibitor.

PF-06840003

🥰Excellent

Purity: 99.10%

Catalog No. T4307Alias PF 06840003, EOS200271Cas No. 198474-05-4

PF-06840003 (EOS200271) is a specific and orally active IDO-1 inhibitor.

Pack Size	Price	Availability
2 mg	$32	In Stock
5 mg	$50	In Stock
10 mg	$85	In Stock
25 mg	$117	In Stock
50 mg	$137	In Stock
100 mg	$216	In Stock
200 mg	$322	In Stock
1 mL x 10 mM (in DMSO)	$55	In Stock

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Purity:99.10%

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Bioactivity

Description	PF-06840003 (EOS200271) is a specific and orally active IDO-1 inhibitor.
Targets&IC50	IDO1 (mouse):1.5 μM, IDO1 (human):0.41 μM, dIDO1:0.59 μM
In vitro	The s of PF-06840003 has inhibitory for hIDO-1 (IC50: 0.41 μM), mouse IDO-1 (IC50: 1.5 μM) and dog IDO-1 (IC50: 0.59 μM), respectively. It has very weak inhibitory against hTDO-2 (IC50: 140 μM). In cellular assays, PF-06840003 shows activity both in the LPS/INFγ-stimulated THP1 cells (IC50: 1.7 μM) and in the HeLa assay (IC50: 1.8 μM). PF-06840003 is a very weak inhibitory against CYPs (IC50>100 μM) except 2C19 (IC50: 78 μM).
In vivo	In mice, PF-06840003 reduces intratumoral kynurenine levels (>80%). In multiple preClinicalal syngeneic models in mice, It inhibits tumor growth by combinated with immune checkpoint inhibitors. PF-0684003 has favorable predicted human pharmacokinetic properties, including a predicted t1/2 of 16-19 hours.
Synonyms	PF 06840003, EOS200271

Chemical Properties

Molecular Weight	232.21
Formula	C₁₂H₉FN₂O₂
Cas No.	198474-05-4
Smiles	Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1
Relative Density.	1.464 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (258.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3064 mL	21.5322 mL	43.0645 mL	215.3223 mL
5 mM	0.8613 mL	4.3064 mL	8.6129 mL	43.0645 mL
10 mM	0.4306 mL	2.1532 mL	4.3064 mL	21.5322 mL
20 mM	0.2153 mL	1.0766 mL	2.1532 mL	10.7661 mL
50 mM	0.0861 mL	0.4306 mL	0.8613 mL	4.3064 mL
100 mM	0.0431 mL	0.2153 mL	0.4306 mL	2.1532 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc