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Plumbagin

Name: Plumbagin
Brand: TargetMol
SKU: T2841
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2841Cas No. 481-42-5

Alias Plumbagone, Plumbagine, Plumbaein, 2-Methyljuglone

Plumbagin (Plumbaein) is a yellow dye, formally derived from naphthoquinone. It is named after the plant genus Plumbago, from which it was originally isolated. It is also commonly found in the carnivorous plant genera Drosera and Nepenthes. It is also a component of the black walnut drupe.

Plumbagin

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Purity: 99.95%

Catalog No. T2841Alias Plumbagone, Plumbagine, Plumbaein, 2-MethyljugloneCas No. 481-42-5

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$34	In Stock	In Stock
25 mg	$54	In Stock	In Stock
50 mg	$77	In Stock	In Stock
100 mg	$112	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.95%

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COA HPLC HNMR

Product Introduction

Plumbagin AI Summary

Plumbagin demonstrates a broad range of biological activities. It inhibits topoisomerase I with a MIC of 50,000 nM and shows significant antitrypanosomal activity against Trypanosoma cruzi with an IC50 of 28,000 nM, while inhibiting human homologous Disulphide oxidoreductase (hGR) with an IC50 of 38,000 nM. The compound has demonstrated in vitro antimalarial activity against Plasmodium falciparum with remarkably varied IC50 values of 2,400 nM and 270 nM, suggesting context-dependent potency. It also shows notable antiparasitic, antibacterial, antifungal, and larvicidal activities, with specific cytotoxic effects on various human cancer cell lines, including MCF7, MDA-MB-231, and several others, achieving IC50 values as low as 3,500 nM. Furthermore, Plumbagin possesses antiviral properties against SARS-CoV-2, antiproliferative activity against multiple human cell lines, and inhibitory actions on several enzymes including p300 and various cytochrome P450 enzymes. Additionally, it exhibits anti-inflammatory effects in a murine model of ulcerative colitis and demonstrates antitumor activity in different cancer cell lines and xenograft models. The compound's multifaceted bioactivity suggests its potential for therapeutic applications across a wide range of diseases and conditions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Plumbagin (Plumbaein) is a yellow dye, formally derived from naphthoquinone. It is named after the plant genus Plumbago, from which it was originally isolated. It is also commonly found in the carnivorous plant genera Drosera and Nepenthes. It is also a component of the black walnut drupe.
Synonyms	Plumbagone, Plumbagine, Plumbaein, 2-Methyljuglone

Chemical Properties

Molecular Weight	188.18
Formula	C₁₁H₈O₃
Cas No.	481-42-5
Smiles	CC1=CC(=O)c2c(O)cccc2C1=O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250.00 mg/mL (1328.52 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1.00 mg/mL (5.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.3141 mL	26.5703 mL	53.1406 mL	265.7031 mL
5 mM	1.0628 mL	5.3141 mL	10.6281 mL	53.1406 mL
10 mM	0.5314 mL	2.6570 mL	5.3141 mL	26.5703 mL
20 mM	0.2657 mL	1.3285 mL	2.6570 mL	13.2852 mL
50 mM	0.1063 mL	0.5314 mL	1.0628 mL	5.3141 mL
100 mM	0.0531 mL	0.2657 mL	0.5314 mL	2.6570 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc