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Necrostatin-5

Catalog No. T37558   CAS 337349-54-9
Synonyms: Nec-5

Necrostatin-5 is a selective inhibitor of RIP1 kinase and a cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with TNF-α with an EC50 value of 240 nM.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Necrostatin-5, CAS 337349-54-9
Pack Size Availability Price/USD Quantity
5 mg In stock $ 42.00
10 mg In stock $ 66.00
25 mg In stock $ 148.00
50 mg In stock $ 217.00
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Purity: 98.03%
Purity: 98.03%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Necrostatin-5 is a selective inhibitor of RIP1 kinase and a cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with TNF-α with an EC50 value of 240 nM.
Targets&IC50 Cell necroptosis inhibitor:240 nM (EC50)
Synonyms Nec-5
Molecular Weight 383.49
Formula C19H17N3O2S2
CAS No. 337349-54-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 4.5 mg/mL (11.7 mM), ultrasonic and warming and heat to 60°C

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. González-Juarbe N, Gilley RP, Hinojosa CA, et al. Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia. PLoS Pathog. 2015;11(12):e1005337. 2. Dmitriev YV, Minasian SM, Demchenko EA, Galagudza MM. Study of cardioprotective effects of necroptosis inhibitors on isolated rat heart subjected to global ischemia-reperfusion. Bull Exp Biol Med. 2013;155(2):245-248.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max NF-κB Signaling Compound Library Anti-Cancer Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets
RIPK1-IN-4 RIPK1-IN-9 HTH-01-091 RIP2 Kinase Inhibitor 3 GSK2593074A OD36 hydrochloride WEHI-345 GSK872 HCl(1346546-69-7 free base)

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Necrostatin-5 337349-54-9 Apoptosis NF-Κb RIP kinase Necroptosis Nec-5 inhibitor inhibit