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β-catenin-IN-2

Name: β-catenin-IN-2
Brand: TargetMol
SKU: T9696
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9696Cas No. 1458664-10-2

β-catenin-IN-2, a potent inhibitor of β-catenin, is suitable for use in colorectal cancer research.

β-catenin-IN-2

🥰Excellent

Purity: 99.93%

Catalog No. T9696Cas No. 1458664-10-2

β-catenin-IN-2, a potent inhibitor of β-catenin, is suitable for use in colorectal cancer research.

Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$239	In Stock
10 mg	$378	In Stock
25 mg	$639	In Stock
50 mg	$913	In Stock
100 mg	$1,230	In Stock
500 mg	$2,490	In Stock
1 mL x 10 mM (in DMSO)	$278	In Stock

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Batch Information

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Purity:99.93%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	β-catenin-IN-2, a potent inhibitor of β-catenin, is suitable for use in colorectal cancer research.
In vitro	In HCT116 cells, β-catenin-IN-2 (10-40 μM) dose-dependently suppressed the transcriptional activity of the β-catenin/Tcf-4 [1].

Chemical Properties

Molecular Weight	255.29
Formula	C₁₅H₁₄FN₃
Cas No.	1458664-10-2
Smiles	CN(C)c1ccc(cc1)-c1nc2ccc(F)cc2[nH]1
Relative Density.	1.260 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.33 mg/mL (326.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9171 mL	19.5856 mL	39.1711 mL	195.8557 mL
5 mM	0.7834 mL	3.9171 mL	7.8342 mL	39.1711 mL
10 mM	0.3917 mL	1.9586 mL	3.9171 mL	19.5856 mL
20 mM	0.1959 mL	0.9793 mL	1.9586 mL	9.7928 mL
50 mM	0.0783 mL	0.3917 mL	0.7834 mL	3.9171 mL
100 mM	0.0392 mL	0.1959 mL	0.3917 mL	1.9586 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc