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ORY1001

Name: ORY1001
Brand: TargetMol
SKU: T6922
Price: 54 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6922Cas No. 1431326-61-2

Alias RG-6016, ORY-1001, ORY 1001

ORY1001 (ORY 1001) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor, with high selectivity against related FAD dependent aminoxidases with IC50 of <20 nM.

ORY1001

🥰Excellent

Purity: 99.96%

Catalog No. T6922Alias RG-6016, ORY-1001, ORY 1001Cas No. 1431326-61-2

ORY1001 (ORY 1001) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor, with high selectivity against related FAD dependent aminoxidases with IC50 of <20 nM.

Pack Size	Price	Availability
1 mg	$54	In Stock
2 mg	$76	In Stock
5 mg	$136	In Stock
10 mg	$246	In Stock
25 mg	$475	In Stock
50 mg	$695	In Stock
100 mg	$988	In Stock
500 mg	$1,980	In Stock
1 mL x 10 mM (in DMSO)	$136	In Stock

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Purity:99.96%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	ORY1001 (ORY 1001) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor, with high selectivity against related FAD dependent aminoxidases with IC50 of <20 nM.
Targets&IC50	LSD1/KDM1A:20 nM
In vitro	In THP-1 (MLL-AF9) cells, ORY-1001 results in a time/dose dependent me2H3K4 accumulation at KDM1A target genes and concomitant induction of differentiation markers. ORY-1001 also induces apoptosis in THP-1 and inhibits proliferation and colony formation of MV(4;11) (MLL-AF4) cells. [1]
In vivo	In rodent MV(4;11) xenografts, ORY-1001 (<0.020 mg/kg, p.o.) leads to significantly reduced tumor growth. [1]
Synonyms	RG-6016, ORY-1001, ORY 1001

Chemical Properties

Molecular Weight	303.27
Formula	C₁₅H₂₂N₂·2HCl
Cas No.	1431326-61-2
Smiles	Cl.Cl.NC1CCC(CC1)N[C@@H]1C[C@H]1c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (32.97 mM), Sonication is recommended.

Ethanol: 1 mg/mL (3.3 mM), Sonication is recommended.

H2O: 56 mg/mL (184.65 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.2974 mL	16.4870 mL	32.9739 mL	164.8696 mL

DMSO/H2O

	1mg	5mg	10mg	50mg
5 mM	0.6595 mL	3.2974 mL	6.5948 mL	32.9739 mL
10 mM	0.3297 mL	1.6487 mL	3.2974 mL	16.4870 mL
20 mM	0.1649 mL	0.8243 mL	1.6487 mL	8.2435 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0659 mL	0.3297 mL	0.6595 mL	3.2974 mL
100 mM	0.0330 mL	0.1649 mL	0.3297 mL	1.6487 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc