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ORY1001

Name: ORY1001
Brand: TargetMol
SKU: T6922
Price: 54 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6922Cas No. 1431326-61-2

Alias RG-6016, ORY-1001, ORY 1001

ORY1001 (ORY 1001) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor, with high selectivity against related FAD dependent aminoxidases with IC50 of <20 nM.

ORY1001

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Purity: 99.96%

Catalog No. T6922Alias RG-6016, ORY-1001, ORY 1001Cas No. 1431326-61-2

ORY1001 (ORY 1001) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor, with high selectivity against related FAD dependent aminoxidases with IC50 of <20 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$54	In Stock	In Stock
2 mg	$76	In Stock	In Stock
5 mg	$136	In Stock	In Stock
10 mg	$246	In Stock	In Stock
25 mg	$475	In Stock	In Stock
50 mg	$695	In Stock	In Stock
100 mg	$988	-	In Stock
500 mg	$1,980	-	In Stock
1 mL x 10 mM (in DMSO)	$136	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.96%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	ORY1001 (ORY 1001) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor, with high selectivity against related FAD dependent aminoxidases with IC50 of <20 nM.
Targets&IC50	LSD1/KDM1A:20 nM
In vitro	In THP-1 (MLL-AF9) cells, ORY-1001 results in a time/dose dependent me2H3K4 accumulation at KDM1A target genes and concomitant induction of differentiation markers. ORY-1001 also induces apoptosis in THP-1 and inhibits proliferation and colony formation of MV(4;11) (MLL-AF4) cells. [1]
In vivo	In rodent MV(4;11) xenografts, ORY-1001 (<0.020 mg/kg, p.o.) leads to significantly reduced tumor growth. [1]
Synonyms	RG-6016, ORY-1001, ORY 1001

Chemical Properties

Molecular Weight	303.27
Formula	C₁₅H₂₂N₂·2HCl
Cas No.	1431326-61-2
Smiles	Cl.Cl.NC1CCC(CC1)N[C@@H]1C[C@H]1c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 7.81 mg/mL (25.75 mM), Sonication is recommended.

Ethanol: 1 mg/mL (3.3 mM), Sonication is recommended.

H2O: 56 mg/mL (184.65 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.2974 mL	16.4870 mL	32.9739 mL	164.8696 mL

DMSO/H2O

	1mg	5mg	10mg	50mg
5 mM	0.6595 mL	3.2974 mL	6.5948 mL	32.9739 mL
10 mM	0.3297 mL	1.6487 mL	3.2974 mL	16.4870 mL
20 mM	0.1649 mL	0.8243 mL	1.6487 mL	8.2435 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0659 mL	0.3297 mL	0.6595 mL	3.2974 mL
100 mM	0.0330 mL	0.1649 mL	0.3297 mL	1.6487 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc