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PC945

Name: PC945
Brand: TargetMol
SKU: T12376
Price: 139 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12376Cas No. 1931946-73-4

Alias Opelconazole

PC945 (Opelconazole) is a potent broad-spectrum antifungal compound with inhibitory effect on fumonisinol 14α-demethylase (CYP51A/CYP51B), which can be used in the study of fungal infections of the lungs.

PC945

🥰Excellent

Purity: 99.37%

Catalog No. T12376Alias OpelconazoleCas No. 1931946-73-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$139	In Stock	In Stock
5 mg	$347	In Stock	In Stock
10 mg	$562	In Stock	In Stock
25 mg	$1,060	In Stock	In Stock
50 mg	$1,630	In Stock	In Stock
100 mg	$2,280	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$522	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.37%

ee:100%

Appearance:Solid

Color:White

Resource Download

COA FNMR HNMR LCMS ORP CSFC

Product Introduction

Bioactivity

Description	PC945 (Opelconazole) is a potent broad-spectrum antifungal compound with inhibitory effect on fumonisinol 14α-demethylase (CYP51A/CYP51B), which can be used in the study of fungal infections of the lungs.
Targets&IC50	CYP51B:0.22 μM, CYP51A:0.23 μM
In vitro	Designed for administration via inhalation, PC945 is a triazole antifungal[1]. PC945 demonstrates the most potent antifungal activity against the azole-susceptible strain NCPF2010, with a MIC value of 0.063 µg/mL[1].
In vivo	Substantially inhibiting the incidence of rolling behavior, PC945 (0.56-14 μg/mouse; intranasal; daily for 7 days) is observed[2].
Synonyms	Opelconazole

Chemical Properties

Molecular Weight	682.73
Formula	C₃₈H₃₇F₃N₆O₃
Cas No.	1931946-73-4
Smiles	Cc1cc(ccc1OC[C@@H]1CO[C@](Cn2cncn2)(C1)c1ccc(F)cc1F)N1CCN(CC1)c1ccc(cc1)C(=O)Nc1ccc(F)cc1
Relative Density.	1.33 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (117.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (4.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4647 mL	7.3235 mL	14.6471 mL	73.2354 mL
5 mM	0.2929 mL	1.4647 mL	2.9294 mL	14.6471 mL
10 mM	0.1465 mL	0.7324 mL	1.4647 mL	7.3235 mL
20 mM	0.0732 mL	0.3662 mL	0.7324 mL	3.6618 mL
50 mM	0.0293 mL	0.1465 mL	0.2929 mL	1.4647 mL
100 mM	0.0146 mL	0.0732 mL	0.1465 mL	0.7324 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc