NT1-O12B

Name: NT1-O12B
Brand: TargetMol
SKU: T38093
Rating: 4.5 (1 reviews)

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Catalog No. T38093

Alias NT1-O12B

NT1-O12B, an endogenous neurotransmitter-derived lipidoid (NT-lipidoid), serves as a highly efficient carrier for enhancing the transportation of various blood-brain barrier (BBB)-impermeable cargos to the brain. Incorporating NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) enables these LNPs to effectively traverse the BBB. In addition to enabling cargo passage through the BBB, NT-lipidoid formulations facilitate efficient delivery of the cargo into neuronal cells for purposes such as functional gene silencing or gene recombination[1].

NT1-O12B

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Catalog No. T38093Alias NT1-O12B

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$291	Inquiry	Inquiry
10 mg	$481	Inquiry	Inquiry
25 mg	$913	Inquiry	Inquiry
50 mg	$1,410	Inquiry	Inquiry
100 mg	$1,990	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$456	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	NT1-O12B, an endogenous neurotransmitter-derived lipidoid (NT-lipidoid), serves as a highly efficient carrier for enhancing the transportation of various blood-brain barrier (BBB)-impermeable cargos to the brain. Incorporating NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) enables these LNPs to effectively traverse the BBB. In addition to enabling cargo passage through the BBB, NT-lipidoid formulations facilitate efficient delivery of the cargo into neuronal cells for purposes such as functional gene silencing or gene recombination[1].
In vitro	NT1-O12B indicates a lipidoid containing a tryptamine head group and a hydrophobic tail group containing 12 carbon atoms[1].
In vivo	The process encapsulates Amphotericin B (AmB) utilizing NT1-lipidoids—specifically NT1-O12B, NT1-O14B, NT1-O16B, and NT1-O18B following a method akin to DiR encapsulation. Among these, NT1-O12B serves as an effective dopant for brain delivery, demonstrating the highest DiR fluorescence intensity compared to the others. Integrating NT1-O12B with the blood-brain barrier (BBB)-impermeable lipidoid PBA-Q76-O16B produces an AmB formulation capable of crossing the BBB. This technique significantly enhances AmB presence in brain tissue, reaching concentrations up to 300 ng/g (AmB/tissue) and achieving a delivery efficiency of approximately 0.135% of the injected dose 24 hours post intravenous administration of AmB (5 mg/kg)[1].
Synonyms	NT1-O12B

Chemical Properties

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Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility Information	DMSO: 200 mg/mL, Sonication is recommended.
In Vivo Formulation	10% DMSO+90% Corn Oil: 5 mg/mL, Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc