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NT1-O12B

Catalog No. T38093

Synonyms: NT1-O12B

NT1-O12B, an endogenous neurotransmitter-derived lipidoid (NT-lipidoid), serves as a highly efficient carrier for enhancing the transportation of various blood-brain barrier (BBB)-impermeable cargos to the brain. Incorporating NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) enables these LNPs to effectively traverse the BBB. In addition to enabling cargo passage through the BBB, NT-lipidoid formulations facilitate efficient delivery of the cargo into neuronal cells for purposes such as functional gene silencing or gene recombination[1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

NT1-O12B, CAS N/A

Pack Size	Availability	Price/USD
5 mg	Inquiry	$ 291.00
10 mg	Inquiry	$ 481.00
25 mg	Inquiry	$ 913.00
50 mg	Inquiry	$ 1,410.00
100 mg	Inquiry	$ 1,990.00
1 mL * 10 mM (in DMSO)	Inquiry	$ 456.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	NT1-O12B, an endogenous neurotransmitter-derived lipidoid (NT-lipidoid), serves as a highly efficient carrier for enhancing the transportation of various blood-brain barrier (BBB)-impermeable cargos to the brain. Incorporating NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) enables these LNPs to effectively traverse the BBB. In addition to enabling cargo passage through the BBB, NT-lipidoid formulations facilitate efficient delivery of the cargo into neuronal cells for purposes such as functional gene silencing or gene recombination[1].
In vitro	NT1-O12B indicates a lipidoid containing a tryptamine head group and a hydrophobic tail group containing 12 carbon atoms[1].
In vivo	The process encapsulates Amphotericin B (AmB) utilizing NT1-lipidoids—specifically NT1-O12B, NT1-O14B, NT1-O16B, and NT1-O18B following a method akin to DiR encapsulation. Among these, NT1-O12B serves as an effective dopant for brain delivery, demonstrating the highest DiR fluorescence intensity compared to the others. Integrating NT1-O12B with the blood-brain barrier (BBB)-impermeable lipidoid PBA-Q76-O16B produces an AmB formulation capable of crossing the BBB. This technique significantly enhances AmB presence in brain tissue, reaching concentrations up to 300 ng/g (AmB/tissue) and achieving a delivery efficiency of approximately 0.135% of the injected dose 24 hours post intravenous administration of AmB (5 mg/kg)[1].

Synonyms	NT1-O12B
Molecular Weight	N/A

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 200 mg/mL (280.45 mM), Sonication is recommended.

References and Literature

1. Ma F, et al. Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection. Sci Adv. 2020;6(30):eabb4429. Published 2020 Jul 24.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NT1-O12B NT1 O12B NT-1-O12B NT1O12B inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.