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GKT136901 hydrochloride

Name: GKT136901 hydrochloride
Brand: TargetMol
SKU: T38646
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38646Cas No. 1254507-01-1

Alias GKT-901 hydrochloride, GKT-771 hydrochloride, GKT-136901 hydrochloride, AK120765 hydrochloride, AK 120765 hydrochloride

GKT136901 hydrochloride is a NOX-1/4 inhibitor, a selective scavenger of peroxynitrite, which inhibits METH-induced ROS production.

GKT136901 hydrochloride

🥰Excellent

Catalog No. T38646Alias GKT-901 hydrochloride, GKT-771 hydrochloride, GKT-136901 hydrochloride, AK120765 hydrochloride, AK 120765 hydrochlorideCas No. 1254507-01-1

GKT136901 hydrochloride is a NOX-1/4 inhibitor, a selective scavenger of peroxynitrite, which inhibits METH-induced ROS production.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	GKT136901 hydrochloride is a NOX-1/4 inhibitor, a selective scavenger of peroxynitrite, which inhibits METH-induced ROS production.
Targets&IC50	NOX1:160 nM (Ki), NOX4:165 nM (Ki)
In vitro	GKT136901 hydrochloride is a potent, selective and orally active NADPH oxidase (NOX1/4) inhibitor with Ki values of 160 nM and 165 nM, respectively. [1] GKT136901 hydrochloride significantly reduced the production of superoxide radical anion and H2O2 in MPT cells induced by high D-glucose and eliminated the effect of high D-glucose on p38MAP kinase activation in MPT cells after treatment with GKT136901 hydrochloride at a dose of 10 μM for 30 min. [3] GKT136901 hydrochloride attenuated methamphetamine (METH)-induced oxidative stress in HBMEC treated at a dose of 10 μM for 2 hours and effectively protected HBMEC from METH-induced blood-brain barrier (BBB) dysfunction. [5]
In vivo	GKT136901 hydrochloride exhibited nephroprotective effects in a mouse model of type 2 diabetes mellitus when administered orally at a dose of 30-90 mg/kg daily for 16 weeks. [6]
Synonyms	GKT-901 hydrochloride, GKT-771 hydrochloride, GKT-136901 hydrochloride, AK120765 hydrochloride, AK 120765 hydrochloride

Chemical Properties

Molecular Weight	403.26
Formula	C₁₉H₁₆Cl₂N₄O₂
Cas No.	1254507-01-1
Smiles	Cl.O=C1C=C2NN(C(=O)C2=C(N1CC3=NC=CC=C3)C)C=4C=CC=CC4Cl
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 2 mg/mL (4.96 mM), Sonication is recommended.

DMSO: 50 mg/mL (123.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.96 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4798 mL	12.3989 mL	24.7979 mL	123.9895 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.4960 mL	2.4798 mL	4.9596 mL	24.7979 mL
10 mM	0.2480 mL	1.2399 mL	2.4798 mL	12.3989 mL
20 mM	0.1240 mL	0.6199 mL	1.2399 mL	6.1995 mL
50 mM	0.0496 mL	0.2480 mL	0.4960 mL	2.4798 mL
100 mM	0.0248 mL	0.1240 mL	0.2480 mL	1.2399 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc