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Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody
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Catalog No. TMAC-00681
Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Siglec-2/CD22 (Tyr807). Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody can be used in WB,IHC-P,IF(paraffin section),ELISA.
Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody
Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody
😃Good
Catalog No. TMAC-00681
Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Siglec-2/CD22 (Tyr807). Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody can be used in WB,IHC-P,IF(paraffin section),ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $216 | 7-10 days | |
| 100 μL | $317 | 7-10 days |
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Chemical Properties
| Description | Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Siglec-2/CD22 (Tyr807). Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody can be used in WB,IHC-P,IF(paraffin section),ELISA. |
| Ig Type | IgG |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-300; ELISA: 1:40000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Appearance | Liquid |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Research Background | alternative products:Additional isoforms seem to exist,domain:Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.,online information:Siglec-2,online information:Siglec-2 [3 Fc Domains],PTM:Phosphorylated on tyrosine residues by LYN.,PTM:Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.,similarity:Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 6 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2, INPP5D and SHC1 upon phosphorylation (By similarity). May form a complex with INPP5D/SHIP, GRB2 and SHC1.,tissue specificity:B-lymphocytes., |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | A synthesized phosphopeptide: human BL-CAM around the phosphorylation site of Tyr807. AA range:776-825 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Actual: 95 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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