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IMMU-114 (Synonyms: IMMU114, hL243)

Catalog No. T77435 Copy Product Info
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IMMU-114 is a humanized antibody targeting HLA-DR, which inhibits human responses to bovine cells, used in malignant tumor research.

IMMU-114

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Catalog No. T77435
Synonyms IMMU114, hL243

IMMU-114 is a humanized antibody targeting HLA-DR, which inhibits human responses to bovine cells, used in malignant tumor research.

IMMU-114
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Pack SizePriceUSA StockGlobal StockQuantity
1 mg$447-In Stock
5 mg$1,400-In Stock
10 mg$2,240-In Stock
25 mg$4,210-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:97.84% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction

Bioactivity
Description
IMMU-114 is a humanized antibody targeting HLA-DR, which inhibits human responses to bovine cells, used in malignant tumor research.
In vitro
IMMU-114 can effectively inhibit human cell response to cattle. The mechanism involves direct inhibition of interactions between Class II human leukocyte antigen DR Positive cells and CD4 (+) T cells, as well as indirect inhibition of Th1 cytokine production. [1]
In allogeneic MLRs, IMMU-114 treatment inhibited T cell proliferation and reduced CD25 (+) alloreactive T cells. [2]
In vivo
In seven human disease models (acute lymphoblastic leukemia (ALL), chronic lymphoblastic leukemia (CLL), multiple myeloma (MM), acute myeloid leukemia (AML), diffuse large B-cell lymphoma (DLBCL), Hodgkin lymphoma (HL), and melanoma), IMMU-114 has anti-tumor effect. [3]
SynonymsIMMU114, hL243
Reactivity
Human
Application
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Gene ID
Uniprot ID
TargetHLA-DR
Chemical Properties
Molecular Weight145.1 kDa
Smiles#N/A
Antibody Information
IsotypeHuman IgG4SP kappa
Recommended Isotype Control
Storage & Solubility Information
Storagestore at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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