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IMMU-114
(Synonyms: IMMU114, hL243) Copy Product Info
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Synonyms: IMMU114, hL243
Catalog No. T77435 Copy Product Info
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IMMU-114 is a humanized antibody that targets HLA-DR. IMMU-114 binds to HLA-DR on the surface of tumor cells, triggering apoptosis and inhibiting cell proliferation. IMMU-114 can be used in research on malignant tumors.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $358 | - | In Stock | |
| 5 mg | $1,120 | - | In Stock | |
| 10 mg | $1,790 | - | In Stock | |
| 25 mg | $3,360 | - | In Stock | |
| 50 mg | Preferential | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:97.84% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Antibody Information
Storage & Solubility Information
| Description | IMMU-114 is a humanized antibody that targets HLA-DR. IMMU-114 binds to HLA-DR on the surface of tumor cells, triggering apoptosis and inhibiting cell proliferation. IMMU-114 can be used in research on malignant tumors. |
| In vitro | IMMU-114 can effectively inhibit human cell response to cattle. The mechanism involves direct inhibition of interactions between Class II human leukocyte antigen DR Positive cells and CD4 (+) T cells, as well as indirect inhibition of Th1 cytokine production. [1] In allogeneic MLRs, IMMU-114 treatment inhibited T cell proliferation and reduced CD25 (+) alloreactive T cells. [2] |
| In vivo | In seven human disease models (acute lymphoblastic leukemia (ALL), chronic lymphoblastic leukemia (CLL), multiple myeloma (MM), acute myeloid leukemia (AML), diffuse large B-cell lymphoma (DLBCL), Hodgkin lymphoma (HL), and melanoma), IMMU-114 has anti-tumor effect. [3] |
| Synonyms | IMMU114, hL243 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | HLA-DR |
| Molecular Weight | 145.1 kDa |
| Smiles | #N/A |
| Isotype | Human IgG4SP kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: IMMU-114 chemical structure | IMMU-114 in vivo | IMMU-114 in vitro | IMMU-114 molecular weight
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