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Anti-IRE1 Antibody (6U65)
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Catalog No. TMAY-02142
Alias IRE1P, IRE1a, IRE1, hIRE1p, endoplasmic reticulum to nucleus signaling 1
Anti-IRE1 Antibody (6U65) is a Mouse antibody targeting IRE1. Anti-IRE1 Antibody (6U65) can be used in ELISA,IHC-P.
Anti-IRE1 Antibody (6U65)
Anti-IRE1 Antibody (6U65)
😃Good
Catalog No. TMAY-02142Alias IRE1P, IRE1a, IRE1, hIRE1p, endoplasmic reticulum to nucleus signaling 1
Anti-IRE1 Antibody (6U65) is a Mouse antibody targeting IRE1. Anti-IRE1 Antibody (6U65) can be used in ELISA,IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-IRE1 Antibody (6U65) is a Mouse antibody targeting IRE1. Anti-IRE1 Antibody (6U65) can be used in ELISA,IHC-P. |
| Alias | IRE1P, IRE1a, IRE1, hIRE1p, endoplasmic reticulum to nucleus signaling 1 |
| Ig Type | Monoclonal Mouse IgG2b |
| Clone | 6U65 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human ERN1 in human tonsil with mouse monoclonal antibody (1:300, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human ERN1 in human liver with mouse monoclonal antibody (1:300, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human ERN1 in human epididymis with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). |
| Application | ELISA,IHC-P |
| Recommended Dose | ELISA: 1:1000-1:2000; IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ERN1 / IRE1 (rh ERN1 / IRE1; TMPY-04413; O75460-1; Pro 465-Leu 977). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell death processes, significantly decreases proliferative processes. An enhanced expression of TP53 gene in ERN1 knockdown glioma cells correlates with the decreased level of ubiquitin ligase MDM2 and increased expression level of USP7 which deubiquitinates TP53 and MDM2 and induces TP53-dependent cell growth repression and apoptosis. Thus, the expression of genes encoding TP53 and related to TP53 factors depends upon the endoplasmic reticulum stress signaling as well as on hypoxia, and correlates with suppression of glioma growth under ERN1 knockdown. The dependence of insulin-like growth binding proteins as well as IGF2BP3 and HTRA1 gene expressions in U87 glioma cells on ERN1 signaling enzyme function and hypoxia, indicating its participation in the regulation of metabolic and proliferative processes via IGF/INS receptors, because endoplasmic reticulum stress is an important component of tumor growth and metabolic diseases. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human ERN1 / IRE1 protein (TMPY-04413) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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