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I2906

Name: I2906
Brand: TargetMol
SKU: T11594
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11594Cas No. 331963-29-2

Alias I 2906

I2906 has antimicrobial activity and inhibits Mycobacterium tuberculosis.

I2906

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Purity: 99.92%

Catalog No. T11594Alias I 2906Cas No. 331963-29-2

I2906 has antimicrobial activity and inhibits Mycobacterium tuberculosis.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$29	-	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.92%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	I2906 has antimicrobial activity and inhibits Mycobacterium tuberculosis.
In vitro	I2906 exhibits excellent antimycobacterial activity and low cytotoxicity. [1]
In vivo	In a mouse model of Mycobacterium tuberculosis H37Rv infection, the bacterial load in the lungs and spleens of mice was significantly reduced after 4 weeks of I2906 treatment compared to untreated controls. In addition, after extending I2906 treatment to 8 weeks, the colony-forming unit counts in the lungs of mice were significantly lower than those of mice treated with isoniazid. Further studies showed that I2906 treatment significantly improved the survival rate of the mice. [1]
Synonyms	I 2906

Chemical Properties

Molecular Weight	443.58
Formula	C₂₅H₃₇N₃O₄
Cas No.	331963-29-2
Smiles	O=C(NNC(=O)CCCCCCCCCCCC)C=1C(=O)N(C=2C=CC=CC2C1O)CC
Relative Density.	1.132 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (33.82 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 1.5 mg/mL (3.38 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2544 mL	11.2719 mL	22.5438 mL	112.7192 mL
5 mM	0.4509 mL	2.2544 mL	4.5088 mL	22.5438 mL
10 mM	0.2254 mL	1.1272 mL	2.2544 mL	11.2719 mL
20 mM	0.1127 mL	0.5636 mL	1.1272 mL	5.6360 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc