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NKP608

Name: NKP608
Brand: TargetMol
SKU: TQ0087
Price: 199 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0087Cas No. 177707-12-9

Alias NKP-608, NKP 608

NKP608 is a selective and highly effective neurokinin-1 (NK-1) receptor antagonist with anticancer and antianxiety activities, inhibiting the proliferation of human colorectal cancer cells through the Wnt signaling pathway.

NKP608

🥰Excellent

Purity: 99.88%

Catalog No. TQ0087Alias NKP-608, NKP 608Cas No. 177707-12-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$199	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.88%

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COA

Product Introduction

Bioactivity

Description	NKP608 is a selective and highly effective neurokinin-1 (NK-1) receptor antagonist with anticancer and antianxiety activities, inhibiting the proliferation of human colorectal cancer cells through the Wnt signaling pathway.
Targets&IC50	HSP:13 nM (gerbil midbrain), HSP:2.6 nM (bovine retina), HSP:27 nM (rat striatum), IP1:2.6 nM
In vitro	NKP608 inhibited the binding of H-SP to bovine retina with an IC50 of 2.6 nM, and to rat striatum and gerbil midbrain membranes with IC50s of 27 and 13 nM. [5] In human astrocytoma cell (U-373) cultures NKP608 inhibited the SP induced increase in IP1 accumulation with an IC50 of 2.6 nM, indicating potent functional antagonism at the human receptor. [5]
In vivo	NKP608 (0.03, 0.1, 0.3, 1 or 3 mg/kg) was given orally 2, 5 or 24 h prior to the i.c.v. administration of 1 mg SPOMe. NKP608 dose-dependently attenuated SPOMe-induced hind foot thumping. [5]
Synonyms	NKP-608, NKP 608

Chemical Properties

Molecular Weight	619.99
Formula	C₃₁H₂₄ClF₆N₃O₂
Cas No.	177707-12-9
Smiles	C([C@H]1N(C(=O)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)CC[C@H](NC(=O)C=3C4=C(N=CC3)C=CC=C4)C1)C5=CC=C(Cl)C=C5
Relative Density.	1.44 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble.

DMSO: 80 mg/mL (129.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6129 mL	8.0646 mL	16.1293 mL	80.6465 mL
5 mM	0.3226 mL	1.6129 mL	3.2259 mL	16.1293 mL
10 mM	0.1613 mL	0.8065 mL	1.6129 mL	8.0646 mL
20 mM	0.0806 mL	0.4032 mL	0.8065 mL	4.0323 mL
50 mM	0.0323 mL	0.1613 mL	0.3226 mL	1.6129 mL
100 mM	0.0161 mL	0.0806 mL	0.1613 mL	0.8065 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc