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NKP608

Name: NKP608
Brand: TargetMol
SKU: TQ0087
Price: 199 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0087Cas No. 177707-12-9

Alias NKP-608, NKP 608

NKP608 is a selective and highly effective neurokinin-1 (NK-1) receptor antagonist with anticancer and antianxiety activities, inhibiting the proliferation of human colorectal cancer cells through the Wnt signaling pathway.

NKP608

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Purity: 99.88%

Catalog No. TQ0087Alias NKP-608, NKP 608Cas No. 177707-12-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$199	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

Appearance:Solid

Color:White to Yellow

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COA

Product Introduction

Bioactivity

Description	NKP608 is a selective and highly effective neurokinin-1 (NK-1) receptor antagonist with anticancer and antianxiety activities, inhibiting the proliferation of human colorectal cancer cells through the Wnt signaling pathway.
Targets&IC50	HSP:13 nM (gerbil midbrain), HSP:27 nM (rat striatum), HSP:2.6 nM (bovine retina), IP1:2.6 nM
In vitro	NKP608 inhibited the binding of H-SP to bovine retina with an IC50 of 2.6 nM, and to rat striatum and gerbil midbrain membranes with IC50s of 27 and 13 nM. [5] In human astrocytoma cell (U-373) cultures NKP608 inhibited the SP induced increase in IP1 accumulation with an IC50 of 2.6 nM, indicating potent functional antagonism at the human receptor. [5]
In vivo	NKP608 (0.03, 0.1, 0.3, 1 or 3 mg/kg) was given orally 2, 5 or 24 h prior to the i.c.v. administration of 1 mg SPOMe. NKP608 dose-dependently attenuated SPOMe-induced hind foot thumping. [5]
Synonyms	NKP-608, NKP 608

Chemical Properties

Molecular Weight	619.99
Formula	C₃₁H₂₄ClF₆N₃O₂
Cas No.	177707-12-9
Smiles	C([C@H]1N(C(=O)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)CC[C@H](NC(=O)C=3C4=C(N=CC3)C=CC=C4)C1)C5=CC=C(Cl)C=C5
Relative Density.	1.44 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble.

DMSO: 80 mg/mL (129.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6129 mL	8.0646 mL	16.1293 mL	80.6465 mL
5 mM	0.3226 mL	1.6129 mL	3.2259 mL	16.1293 mL
10 mM	0.1613 mL	0.8065 mL	1.6129 mL	8.0646 mL
20 mM	0.0806 mL	0.4032 mL	0.8065 mL	4.0323 mL
50 mM	0.0323 mL	0.1613 mL	0.3226 mL	1.6129 mL
100 mM	0.0161 mL	0.0806 mL	0.1613 mL	0.8065 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc