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Ethylene thiourea

Name: Ethylene thiourea
Brand: TargetMol
SKU: T20110
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20110Cas No. 96-45-7

Alias NCI-C03372, NCIC03372, NCI C03372, Imidazolidinethione, ETU

Ethylene thiourea (NCIC03372) is a pesticide used in fruit and vegetable production. Ethylene thiourea is also used as a novel contrast agent for MRI studies based on proton chemical exchange-dependent saturation transfer.

Ethylene thiourea

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Catalog No. T20110Alias NCI-C03372, NCIC03372, NCI C03372, Imidazolidinethione, ETUCas No. 96-45-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:≥98%

Appearance:Solid

Color:White

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COA HNMR

Product Introduction

Ethylene thiourea AI Summary

Ethylene thiourea exhibits a diverse range of bioactivities and cytotoxic properties: - It inhibits the growth of friend leukemia cells, achieving a cell growth rate of 128.0% relative to the untreated control on day 3, and friend erythroleukemia cells, with a cell growth rate of 62.0% of control on day 6. - The compound promotes erythroid maturation, with an increase in benzidine-positive cells to 21.0% at a concentration of 4 mM. - It demonstrates cytotoxic activity with a potency of 2511.9 nM and acts as a potent antagonist of androgen receptor signaling with a potency of 2.2 nM. - Ethylene thiourea shows hepatotoxicity in mice with a pTD50 value of 3.341. - It is highly potent in inhibiting HP1-beta Chromodomain interactions (100000.0 nM), and in the Luminescence Cell-Based Dose Confirmation assay (> 195000.0 nM) targeting Heat Shock Factor 1 (HSF1) inhibitors. - The compound shows moderate activity in inhibiting the Anthrax Lethal Toxin Internalization assay (31622.8 nM) and in the Inhibitors of TGF-b: Cytotox Counterscreen assay (25118.9 nM). - It induces DNA re-replication in MCF 10a normal breast cells (3264.3 nM) and acts as an agonist of the antioxidant response element (ARE) signaling pathway (66824.2 nM). - Additionally, it inhibits the ERG Ets/DNA interaction (1995.3 nM) and human tyrosyl-DNA phosphodiesterase 1 (TDP1) in the presence of CPT (259.3 nM). - Ethylene thiourea also functions as an antagonist of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway (149.6 nM). - Finally, it has activity at the human TAS2R38 receptor in HEK-293T-Galpha16-gustducin44 cells, with a threshold concentration of 10.0 uM as measured by calcium response using the FLIPR assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ethylene thiourea (NCIC03372) is a pesticide used in fruit and vegetable production. Ethylene thiourea is also used as a novel contrast agent for MRI studies based on proton chemical exchange-dependent saturation transfer.
Synonyms	NCI-C03372, NCIC03372, NCI C03372, Imidazolidinethione, ETU

Chemical Properties

Molecular Weight	102.16
Formula	C₃H₆N₂S
Cas No.	96-45-7
Smiles	S=C1NCCN1
Relative Density.	1.41~1.45

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (538.37 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (48.94 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	9.7886 mL	48.9428 mL	97.8857 mL	489.4283 mL
5 mM	1.9577 mL	9.7886 mL	19.5771 mL	97.8857 mL
10 mM	0.9789 mL	4.8943 mL	9.7886 mL	48.9428 mL
20 mM	0.4894 mL	2.4471 mL	4.8943 mL	24.4714 mL
50 mM	0.1958 mL	0.9789 mL	1.9577 mL	9.7886 mL
100 mM	0.0979 mL	0.4894 mL	0.9789 mL	4.8943 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc