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Anti-LAMP1 Antibody-HRP (8V752)

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Catalog No. TMAY-01759H
Alias lysosomal-associated membrane protein 1

Anti-LAMP1 Antibody-HRP (8V752) is a HRP-conjugated Mouse antibody targeting LAMP1. Anti-LAMP1 Antibody-HRP (8V752) can be used in ELISA.

Anti-LAMP1 Antibody-HRP (8V752)

Anti-LAMP1 Antibody-HRP (8V752)

😃Good
Catalog No. TMAY-01759HAlias lysosomal-associated membrane protein 1
Anti-LAMP1 Antibody-HRP (8V752) is a HRP-conjugated Mouse antibody targeting LAMP1. Anti-LAMP1 Antibody-HRP (8V752) can be used in ELISA.
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20 μg$94 7-10 days
100 μg$293 7-10 days
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Product Introduction

Bioactivity
Description
Anti-LAMP1 Antibody-HRP (8V752) is a HRP-conjugated Mouse antibody targeting LAMP1. Anti-LAMP1 Antibody-HRP (8V752) can be used in ELISA.
Aliaslysosomal-associated membrane protein 1
Ig Type
Monoclonal Mouse IgG1
Clone
8V752
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 0.1-1 μg/mL
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human LAMP1 extracellular domain (rh LAMP1; TMPY-01253; NP_005552.3; Met 1-Met 382). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with horseradish-peroxidase (HRP).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundLysosome-associated membrane glycoprotein 1, also known as CD107 antigen-like family member A, CD107a, and LAMP1, is a single-pass type I membrane protein that belongs to the LAMP family. CD107a is expressed largely in the endosome-lysosome membranes of cells but is also found on the plasma membrane (1-2% of total LAMP1). LAMP1 has been implicated in a variety of cellular functions, including cancer metastasis. It has been proposed LAMP1 serves as a therapeutic agent for some cancers, as well as a marker for lysosomal storage disorders and different cell types such as cytotoxic T cells. LAMP2, also known as CD107b, may also play a role in tumor cell metastasis and functions in the protection, maintenance, and adhesion of the lysosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation. LAMP-1 is a glycoprotein highly expressed in lysosomal membranes. The present study was initiated to test LAMP-1 mRNA and protein levels in post mortem frontal cortex (area 8) of Alzheimer's disease (AD) stages I-IIA/B and stages V-VIC of Braak and Braak, compared with age-matched controls. LAMP-1 occurred in microglia and multinucleated giant cells in one AD case in which amyloid burden was cleared following beta A-peptide immunization. Also, LAMP-1 has been suggested to be a cell surface receptor for a specific amelogenin isoform, leucine-rich amelogenin peptide, or LRAP. LAMP-1 can serve as a cell surface binding site for amelogenin on dental follicle cells and cementoblasts.
Related Conjugates and Formulations
Conjucates
HRP
Others Formats
Unconjugated
Antibody Types Available
2
Antigen Details
Immunogen
Recombinant Human LAMP1 protein (TMPY-01253)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. Keep away from direct sunlight.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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