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CM-579

Name: CM-579
Brand: TargetMol
SKU: T10840L
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T10840LCas No. 1846570-40-8

CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.

CM-579

🥰Excellent

Purity: 99.23%

Catalog No. T10840LCas No. 1846570-40-8

CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.

Pack Size	Price	Availability
1 mg	$50	In Stock
5 mg	$97	In Stock
10 mg	$141	In Stock
25 mg	$229	In Stock
50 mg	$336	In Stock
100 mg	$496	In Stock
1 mL x 10 mM (in DMSO)	$126	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.23%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
Targets&IC50	DNMT3B:1000 nM, G9a:16 nM, DNMT3A:92 nM, DNA methyltransferase:32 nM, DNMT1:1.5 nM （kd）
In vitro	CM-579 inhibits DNMT3A and DNMT3B ( IC50s: 92 nM and 1000 nM). The Kd of CM-579 for DNMT1 is 1.5 nM. [1]

Chemical Properties

Molecular Weight	492.65
Formula	C₂₉H₄₀N₄O₃
Cas No.	1846570-40-8
Smiles	N(CC1CCN(C)CC1)C=2C3=C(N=C(C2)C=4OC(C)=CC4)C=C(OCCCN5CCCC5)C(OC)=C3
Relative Density.	1.143 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (91.34 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0298 mL	10.1492 mL	20.2984 mL	101.4919 mL
5 mM	0.4060 mL	2.0298 mL	4.0597 mL	20.2984 mL
10 mM	0.2030 mL	1.0149 mL	2.0298 mL	10.1492 mL
20 mM	0.1015 mL	0.5075 mL	1.0149 mL	5.0746 mL
50 mM	0.0406 mL	0.2030 mL	0.4060 mL	2.0298 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc