Shopping Cart

Your shopping cart is currently empty

CM-579

Name: CM-579
Brand: TargetMol
SKU: T10840L
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Synonyms:

Catalog No. T10840L Copy Product Info

Purity: 99.23%

😃Good

CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.

Cas No. 1846570-40-8

Pack Size	Price	USA Stock	Global Stock
1 mg	$50	In Stock	In Stock
5 mg	$97	In Stock	In Stock
10 mg	$141	In Stock	In Stock
25 mg	$229	In Stock	In Stock
50 mg	$336	In Stock	In Stock
100 mg	$496	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$126	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:99.23%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
Targets & IC50	DNMT3B:1000 nM, G9a:16 nM, DNMT3A:92 nM, DNA methyltransferase:32 nM, DNMT1:1.5 nM （kd）
In vitro	CM-579 inhibits DNMT3A and DNMT3B ( IC50s: 92 nM and 1000 nM). The Kd of CM-579 for DNMT1 is 1.5 nM. [1]

Chemical Properties

Molecular Weight	492.65
Formula	C₂₉H₄₀N₄O₃
Cas No.	1846570-40-8
Smiles	N(CC1CCN(C)CC1)C=2C3=C(N=C(C2)C=4OC(C)=CC4)C=C(OCCCN5CCCC5)C(OC)=C3
Relative Density.	1.143 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.3 mg/mL (169.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 8.33 mg/mL (16.91 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0298 mL	10.1492 mL	20.2984 mL	101.4919 mL
5 mM	0.4060 mL	2.0298 mL	4.0597 mL	20.2984 mL
10 mM	0.2030 mL	1.0149 mL	2.0298 mL	10.1492 mL
20 mM	0.1015 mL	0.5075 mL	1.0149 mL	5.0746 mL
50 mM	0.0406 mL	0.2030 mL	0.4060 mL	2.0298 mL
100 mM	0.0203 mL	0.1015 mL	0.2030 mL	1.0149 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc