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RP-1664

Name: RP-1664
Brand: TargetMol
SKU: T206047
Rating: 4.5 (1 reviews)

🥰Excellent

Catalog No. T206047Cas No. 2980682-00-4

Alias RP1664

RP-1664 is a selective and orally active PLK4 inhibitor with an IC50 of 3 nM. This compound demonstrates exceptional selectivity over related kinases, disrupts centriole biogenesis in cancer cells leading to PLK4 and p21 protein accumulation, shows enhanced sensitivity in TRIM37-high-expressing cells, and exhibits antitumor activity in breast cancer and neuroblastoma research.

RP-1664

🥰Excellent

Purity: 99.04%

Catalog No. T206047Alias RP1664Cas No. 2980682-00-4

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Purity:99.04%

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Product Introduction

Bioactivity

Description	RP-1664 is a selective and orally active PLK4 inhibitor with an IC50 of 3 nM. This compound demonstrates exceptional selectivity over related kinases, disrupts centriole biogenesis in cancer cells leading to PLK4 and p21 protein accumulation, shows enhanced sensitivity in TRIM37-high-expressing cells, and exhibits antitumor activity in breast cancer and neuroblastoma research.
In vitro	Methods: RPE1-hTERT Cas9 TP53 knockout cells and RPE1-hTERT Cas9 TP53 wild-type cells were treated with RP-1664 (1-1000 nM, 48-72 hours), and the expression of target proteins was analyzed by Western Blot. Results: The total protein level of PLK4 was increased in RPE1-hTERT Cas9 TP53 knockout cells, and the level of p21 protein was increased in RPE1-hTERT Cas9 TP53 wild-type cells in a dose-dependent manner. [1]
Synonyms	RP1664

Chemical Properties

Molecular Weight	514.55
Formula	C₂₃H₂₄F₂N₈O₂S
Cas No.	2980682-00-4
Smiles	O=S(=O)(C1=CC(F)=C(C(F)=C1)N(C=2N=C(NC3=NNC(=C3)C)C(=C(N2)C=4N=CN(C4)C)C5CC5)C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (155.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9434 mL	9.7172 mL	19.4345 mL	97.1723 mL
5 mM	0.3887 mL	1.9434 mL	3.8869 mL	19.4345 mL
10 mM	0.1943 mL	0.9717 mL	1.9434 mL	9.7172 mL
20 mM	0.0972 mL	0.4859 mL	0.9717 mL	4.8586 mL
50 mM	0.0389 mL	0.1943 mL	0.3887 mL	1.9434 mL
100 mM	0.0194 mL	0.0972 mL	0.1943 mL	0.9717 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc