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LRRK2

Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin (from the Basque word "dardara" which means trembling) and PARK8 (from early identified association with Parkinson's disease), is a kinase enzyme that in humans is encoded by the LRRK2 gene. LRRK2 is a member of the leucine-rich repeat kinase family. Variants of this gene are associated with an increased risk of Parkinson's disease and also Crohn's disease.

  • LRRK2 inhibitor 1
    T118781802525-61-6In house
    LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM.
    • $68
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  • LRRK2-IN-7
    T731762307277-93-4In house
    LRRK2-IN-7 is a selective, CNS permeable and potent LRRK2 kinase inhibitor (IC50: 0.9 nM) for the study of Parkinson's disease.
    • $239
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  • CCG-1423
    T2014285986-88-1
    CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
    • $32
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    TargetMol | Citations Cited
  • BIX 02565
    T54281311367-27-7
    BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).
    • $56
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    TargetMol | Citations Cited
  • LRRK2-IN-1
    T22461234480-84-2
    LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.
    • $60
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    TargetMol | Citations Cited
  • MK-1468
    T817852769107-89-1
    MK-1468, a highly selective and brain-penetrant LRRK2 inhibitor, exhibits an IC50 of 0.8 nM and is utilized in the study of Parkinson's disease [1].
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    TargetMol | Inhibitor Sale
  • CZC-25146 hydrochloride
    T51391330003-04-7
    CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM 6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
    • $50
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  • CZC-54252 hydrochloride
    T392021784253-05-9
    CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of 1 nM.
    • $32
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  • CZC-25146
    T30531191911-26-8
    CZC-25146 (CHEMBL2397014) is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G2019S LRRK2, respectively.
    • $30
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  • GNE-7915
    T19451351761-44-8
    GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.
    • $39
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  • GSK2578215A
    T22401285515-21-0
    GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
    • $45
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  • LRRK2-IN-10
    T797462704562-80-9
    LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2 pS935 and 5.2 nM for G2019S-LRRK2 pS1292. It holds promise for research into Parkinson's disease [1].
    • $1,520
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  • HG-10-102-01
    T71961351758-81-0
    HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
    • $38
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  • PFE-360
    T165121527475-61-1
    PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).
    • $68
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  • EB-42486
    T399722390475-81-5
    EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.
    • $107
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  • IKK 16
    T6176873225-46-8
    IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
    • $34
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  • GNE0877
    T60311374828-69-9
    GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).
    • $39
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  • URMC-099
    T60571229582-33-5
    URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
    • $52
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  • GNE-9605
    T17701536200-31-3
    GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).
    • $32
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  • MLi-2
    T161151627091-47-7
    MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM), and a radioligand competition binding assay (IC50 = 3.4 nM).
    • $60
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  • PF-06447475
    T20501527473-33-1
    PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3 11 nM for wild type LRRK2 and G2019S LRRK2 respectively.
    • $43
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  • CZC-54252
    T20221191911-27-9
    CZC-54252 is a potent inhibitor of LRRK2.
    • $32
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  • PF-06454589
    T77291527473-30-8
    PF-06454589 is a potent inhibitor of LRRK2.
    • $33
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  • JH-II-127
    T71551700693-08-8
    JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, respectively),
    • $45
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