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ABT 724 trihydrochloride

Name: ABT 724 trihydrochloride
Brand: TargetMol
SKU: T22019
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T22019Cas No. 587870-77-7

ABT 724 trihydrochloride is an effective and selective agonist of the D4 receptor (EC50 = 12.4 nM, 14.3 nM, and 23.2 nM for human, rat and ferret, respectively). ABT-724 trihydrochloride can be used in erectile dysfunction studies.

ABT 724 trihydrochloride

🥰Excellent

Purity: 99.91%

Catalog No. T22019Cas No. 587870-77-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$34	In Stock	In Stock
10 mg	$59	In Stock	In Stock
25 mg	$128	In Stock	In Stock
50 mg	$198	In Stock	In Stock
100 mg	$297	In Stock	In Stock
200 mg	$442	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$37	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ABT 724 trihydrochloride is an effective and selective agonist of the D4 receptor (EC50 = 12.4 nM, 14.3 nM, and 23.2 nM for human, rat and ferret, respectively). ABT-724 trihydrochloride can be used in erectile dysfunction studies.
Targets&IC50	D4 receptor:23.2(EC50, ferret), D4 receptor:12.4 nM(EC50,human), D4 receptor:14.3 nM(EC50, rat)
In vitro	A weak affinity to 5-HT1A receptors (Ki = 2780 nM) is observed. ABT 724 trihydrochloride(10 μM) exhibits a selective biochemical profile, as indicated by a lack of binding affinity for >70 neurotransmitter/uptake/ion channels including D2, D3, or D5 receptors. ABT 724 trihydrochloride(10 μM) does not inhibit the PDE activity of PDE1, PDE5, or PDE6[1].
In vivo	In male adult Wistar rats, ABT 724 trihydrochloride (8.8 μg/kg; s.c.) treatment facilitated penile erection in a dose-dependent manner[1].

Chemical Properties

Molecular Weight	402.75
Formula	C₁₇H₂₂Cl₃N₅
Cas No.	587870-77-7
Smiles	N1(C2=CC=CC=N2)CCN(CC3=NC4=CC=CC=C4N3)CC1.Cl.Cl.Cl
Relative Density.	1.31g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (248.29 mM), Sonication is recommended.

DMSO: 60 mg/mL (148.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.4829 mL	12.4146 mL	24.8293 mL	124.1465 mL
5 mM	0.4966 mL	2.4829 mL	4.9659 mL	24.8293 mL
10 mM	0.2483 mL	1.2415 mL	2.4829 mL	12.4146 mL
20 mM	0.1241 mL	0.6207 mL	1.2415 mL	6.2073 mL
50 mM	0.0497 mL	0.2483 mL	0.4966 mL	2.4829 mL
100 mM	0.0248 mL	0.1241 mL	0.2483 mL	1.2415 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc