Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.It has also been shown to have anti-oxidant and anti-inflammatory activities, contributing to immunomodulatory and hepatoprotective effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 41.00 | |
10 mg | In stock | $ 60.00 | |
25 mg | In stock | $ 108.00 | |
50 mg | In stock | $ 162.00 | |
100 mg | In stock | $ 238.00 | |
500 mg | In stock | $ 595.00 | |
1 g | In stock | $ 848.00 |
Description | Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.It has also been shown to have anti-oxidant and anti-inflammatory activities, contributing to immunomodulatory and hepatoprotective effects. |
In vivo | Pretreatment with zerumbone not only reduced leukocytes infiltration into the alveolar space but also inhibited lung edema in LPS-induced ALI. Decreased secretion of proinflammatory cytokines such as TNFα and IL-6 caused by LPS were reversed by zerumbone. LPS-induced expressions of proinflammatory mediators, iNOS and COX-2, were inhibited by zerumbone. In addition, NFκB activation and Akt phosphorylation were inhibited by zerumbone in LPS-induced ALI. Suggested that the protective mechanisms of zerumbone on endotoxin-induced ALI were via inhibition of Akt-NFκB activation. |
Animal Research | Mice were pretreated with zerumbone at various concentrations for 30 min followed by intratracheal administration of LPS for 6 h.Pretreatment with zerumbone not only reduced leukocytes infiltration into the alveolar space but also inhibited lung edema in LPS-induced ALI. Decreased secretion of proinflammatory cytokines such as TNFα and IL-6 caused by LPS were reversed by zerumbone. |
Source |
Molecular Weight | 218.33 |
Formula | C15H22O |
CAS No. | 471-05-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 44 mg/mL (201.53 mM)
You can also refer to dose conversion for different animals. More
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